Prognostic value of FOXA1 in breast cancer: A systematic review and meta-analysis

被引：32

作者：

Shou, Jiafeng ^{[1
]}

Lai, Yucheng ^{[1
]}

Xu, Jinming ^{[1
]}

Huang, Jian ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Natl Minist Educ,Prov Key Lab Mol Biol Med Sci, Canc Inst,Key Lab Canc Prevent & Intervent,Sch Me, Hangzhou 31009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Oncol, Affiliated Hosp 2, Hangzhou 31009, Zhejiang, Peoples R China

来源：

BREAST | 2016年 / 27卷

关键词：

Breast cancer; FOXA1; Prognosis; RECEPTOR FUNCTION; EXPRESSION; TRANSCRIPTION; CHEMOTHERAPY; DETERMINANT; STATISTICS; REVEALS; IMPACT; GATA-3; DOMAIN;

D O I：

10.1016/j.breast.2016.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite some published papers analyzing the prognostic role of forkhead-box A1 (FOXA1) in breast cancer, it has not yet been considered as an established prognostic factor in clinical practice. The present meta-analysis evaluated the prognostic value of FOXA1 in breast cancer. Methods: PubMed, Web of Science and Embase databases were searched for relevant published literature that evaluated the correlation between FOXA1 and breast cancer. Either a fixed or random effect model was applied to estimate the pooled hazard ratio (HR) for FOXA1 prognosis in breast cancer. Result: A total of nine articles comprising 6386 breast cancer patients met the inclusion criteria. Among these nine studies, five studies and four studies investigated the prognostic association with disease-free survival (DFS), and overall survival (OS), respectively. Meta-analysis results suggested that high FOXA1 expression was positively associated with DFS (pooled HR: 0.43, 95% CI: 0.23-0.81; P < 0.05) and OS (pooled HR: 0.39, 95% CI: 0.26-0.60; P < 0.05) in breast cancer patients. No publication bias was discovered by Begg's test in this meta-analysis. Conclusion: The results from this meta-analysis indicated that elevated FOXA1 expression level was associated with better outcome in breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：35 / 43

页数：9

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