Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

被引：39

作者：

Allott, L. ^{[1
]}

Da Pieve, C. ^{[1
]}

Meyers, J. ^{[2
]}

Spinks, T. ^{[1
]}

Ciobota, D. M. ^{[1
]}

Kramer-Marek, G. ^{[1
]}

Smith, G. ^{[1
]}

机构：

[1] Inst Canc Res, Div Radiotherapy & Imaging, 123 Old Brompton Rd, London, England

[2] Inst Canc Res, Div Canc Therapeut, Canc Res UK Canc Therapeut Unit, 123 Old Brompton Rd, London, England

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 61期

基金：

英国惠康基金;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MONOCLONAL-ANTIBODIES; HYDROXAMATE LIGANDS; ZR-89; RADIOCHEMISTRY;

D O I：

10.1039/c7cc03572a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The future of Zr-89-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for Zr-89 and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with Zr-89. This work broadens the selection of available chelators for Zr-89 in search of improved successors to DFO for clinical Zr-89-immuno-PET.

引用

页码：8529 / 8532

页数：4

共 20 条

[1] Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging [J].

Boros, Eszter ;

Holland, Jason P. ;

Kenton, Nathaniel ;

Rotile, Nicholas ;

Caravan, Peter .

CHEMPLUSCHEM, 2016, 81 (03) :274-281

[2] Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO) [J].

Deri, Melissa A. ;

Ponnala, Shashikanth ;

Zeglis, Brian M. ;

Pohl, Gabor ;

Dannenberg, J. J. ;

Lewis, Jason S. ;

Francesconi, Lynn C. .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (11) :4849-4860

[3] PET imaging with 89Zr: From radiochemistry to the clinic [J].

Deri, Melissa A. ;

Zeglis, Brian M. ;

Francesconi, Lynn C. ;

Lewis, Jason S. .

NUCLEAR MEDICINE AND BIOLOGY, 2013, 40 (01) :3-14

[4] 89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges [J].

Fischer, Gabriel ;

Seibold, Uwe ;

Schirrmacher, Ralf ;

Waengler, Bjoern ;

Waengler, Carmen .

MOLECULES, 2013, 18 (06) :6469-6490

[5] Rational Design, Synthesis, and Evaluation of Tetrahydroxamic Acid Chelators for Stable Complexation of Zirconium( IV) [J].

Guerard, Francois ;

Lee, Yong-Sok ;

Brechbiel, Martin W. .

CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (19) :5584-5591

[6] Charting the mechanism and reactivity of zirconium oxalate with hydroxamate ligands using density functional theory: implications in new chelate design [J].

Holland, Jason P. ;

Vasdev, Neil .

DALTON TRANSACTIONS, 2014, 43 (26) :9872-9884

[7] 89Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo [J].

Holland, Jason P. ;

Divilov, Vadim ;

Bander, Neil H. ;

Smith-Jones, Peter M. ;

Larson, Steven M. ;

Lewis, Jason S. .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (08) :1293-1300

[8] Immuno-Positron Emission Tomography with Zirconium-89-Labeled Monoclonal Antibodies in Oncology: What Can We Learn from Initial Clinical Trials? [J].

Jauw, Yvonne W. S. ;

Menke-van der Houven van Oordt, C. Willemien ;

Hoekstra, Otto S. ;

Hendrikse, N. Harry ;

Vugts, Danielle J. ;

Zijlstra, Josee M. ;

Huisman, Marc C. ;

van Dongen, Guus A. M. S. .

FRONTIERS IN PHARMACOLOGY, 2016, 7

[9] Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: comparison with desferrioxamine-B [J].

Ma, Michelle T. ;

Meszaros, Levente K. ;

Paterson, Brett M. ;

Berry, David J. ;

Cooper, Maggie S. ;

Ma, Yongmin ;

Hiderd, Robert C. ;

Blower, Philip J. .

DALTON TRANSACTIONS, 2015, 44 (11) :4884-4900

[10] Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development [J].

Pandya, Darpan N. ;

Bhatt, Nikunj ;

Yuan, Hong ;

Day, Cynthia S. ;

Ehrmann, Brandie M. ;

Wright, Marcus ;

Bierbach, Ulrich ;

Wadas, Thaddeus J. .

CHEMICAL SCIENCE, 2017, 8 (03) :2309-2314

← 1 2 →