Curcumin, Hormesis and the Nervous System

被引：126

作者：

Scuto, Maria Concetta ^{[1
]}

Mancuso, Cesare ^{[2
,3
]}

Tomasello, Barbara ^{[1
]}

Ontario, Maria Laura ^{[1
]}

Cavallaro, Andrea ^{[1
]}

Frasca, Francesco ^{[4
]}

Maiolino, Luigi ^{[5
]}

Salinaro, Angela Trovato ^{[1
]}

Calabrese, Edward J. ^{[6
]}

Calabrese, Vittorio ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Torre Biol, Via Santa Sofia 97, I-95125 Catania, Italy

[2] Fdn Policlinico Univ A Gemelli IRCCS, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Pharmacol, I-00168 Rome, Italy

[4] Univ Catania, Div Endocrinol, Dept Clin & Expt Med, I-95125 Catania, Italy

[5] Univ Catania, Dept Med & Surg Sci, I-95125 Catania, Italy

[6] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

NUTRIENTS | 2019年 / 11卷 / 10期

关键词：

hormesis; vitagenes; antioxidants; heme oxygenase; HIGHLY BIOAVAILABLE CURCUMIN; CELLULAR STRESS RESPONSES; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; HEME OXYGENASE-1; CARBON-MONOXIDE; STIMULATES PROLIFERATION; DIETARY ANTIOXIDANTS; LOADED NANOPARTICLES; SODIUM-NITROPRUSSIDE;

D O I：

10.3390/nu11102417

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.

引用

页数：17

共 151 条

[81] Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function [J].