Do we need to reconsider how we design and conduct randomized controlled trials?

被引:3
作者
Batra, Gorav [1 ]
Wallentin, Lars
机构
[1] Uppsala Univ, Dept Med Sci Cardiol, Uppsala Sci Pk,Dag Hammarskjolds Vag 38, S-75185 Uppsala, Sweden
关键词
MYOCARDIAL-INFARCTION; EXTERNAL VALIDITY; CLINICAL-TRIALS;
D O I
10.1093/ehjqcco/qcac010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:374 / 376
页数:3
相关论文
共 14 条
[1]   Methodology for the development of international clinical data standards for common cardiovascular conditions: European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) [J].
Batra, Gorav ;
Aktaa, Suleman ;
Wallentin, Lars ;
Maggioni, Aldo P. ;
Wilkinson, Chris ;
Casadei, Barbara ;
Gale, Chris P. .
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES, 2023, 9 (02) :161-168
[2]   Outcome of ST-elevation myocardial infarction treated with thrombolysis in the unselected population is vastly different from samples of eligible patients in a large-scale, clinical trial [J].
Björklund, E ;
Lindahl, B ;
Stenestrand, U ;
Swahn, E ;
Dellborg, M ;
Pehrsson, K ;
Van De Werf, F ;
Wallentin, L .
AMERICAN HEART JOURNAL, 2004, 148 (04) :566-573
[3]   Assessing the Gold Standard - Lessons from the History of RCTs [J].
Bothwell, Laura E. ;
Greene, Jeremy A. ;
Podolsky, Scott H. ;
Jones, David S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (22) :2175-2181
[4]   Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction [J].
Frobert, Ole ;
Lagerqvist, Bo ;
Olivecrona, Goran K. ;
Omerovic, Elmir ;
Gudnason, Thorarinn ;
Maeng, Michael ;
Aasa, Mikael ;
Angeras, Oskar ;
Calais, Fredrik ;
Danielewicz, Mikael ;
Erlinge, David ;
Hellsten, Lars ;
Jensen, Ulf ;
Johansson, Agneta C. ;
Karegren, Amra ;
Nilsson, Johan ;
Robertson, Lotta ;
Sandhall, Lennart ;
Sjogren, Iwar ;
Ostlund, Ollie ;
Harnek, Jan ;
James, Stefan K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (17) :1587-1597
[5]   2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation [J].
Ibanez, Borja ;
James, Stefan ;
Agewall, Stefan ;
Antunes, Manuel J. ;
Bucciarelli-Ducci, Chiara ;
Bueno, Hector ;
Caforio, Alida L. P. ;
Crea, Filippo ;
Goudevenos, John A. ;
Halvorsen, Sigrun ;
Hindricks, Gerhard ;
Kastrati, Adnan ;
Lenzen, Mattie J. ;
Prescott, Eva ;
Roffi, Marco ;
Valgimigli, Marco ;
Varenhorst, Christoph ;
Vranckx, Pascal ;
Widimsky, Petr .
KARDIOLOGIA POLSKA, 2018, 76 (02) :229-313
[6]   Registry-based randomized clinical trials-a new clinical trial paradigm [J].
James, Stefan ;
Rao, Sunil V. ;
Granger, Christopher B. .
NATURE REVIEWS CARDIOLOGY, 2015, 12 (05) :312-316
[7]   Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden [J].
Lagerqvist, Bo ;
James, Stefan K. ;
Stenestrand, Ulf ;
Lindback, Johan ;
Nilsson, Tage ;
Wallentin, Lars .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (10) :1009-1019
[8]   The Randomized Registry Trial - The Next Disruptive Technology in Clinical Research? [J].
Lauer, Michael S. ;
D'Agostino, Ralph B., Sr. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (17) :1579-1581
[9]   Treating Individuals 1 - External validity of randomised controlled trials: "To whom do the results of this trial apply?"' [J].
Rothwell, PM .
LANCET, 2005, 365 (9453) :82-93
[10]  
Sleight Peter, 2000, Curr Control Trials Cardiovasc Med, V1, P25, DOI 10.1186/CVM-1-1-025