Progress of Research on Exosomes in the Protection Against Ischemic Brain Injury

被引：39

作者：

Kang, Xianhui ^{[1
,2
]}

Zuo, Ziyi ^{[3
]}

Hong, Wandong ^{[4
]}

Tang, Hongli ^{[1
]}

Geng, Wujun ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Clin Coll 1, Wenzhou, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Wenzhou, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷

关键词：

exosomes; brain protection; ischemic brain injury; stroke; drug delivery; MESENCHYMAL STROMAL CELLS; FUNCTIONAL RECOVERY; MEDIATED TRANSFER; SECRETION; REPERFUSION; DELIVERY; BIOGENESIS; RATS;

D O I：

10.3389/fnins.2019.01149

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exosomes, as a type of extracellular vesicle (EV), are lipid bilayer vesicles 20-100 nm in diameter that can cross the blood-brain barrier. Exosomes are important transport vesicles in the human body that participate in many conduction pathways and play an important physiological role. Because of their high biocompatibility and low immunogenicity and toxicity, exosomes have attracted increasing attention as an attractive drug delivery system. This article reviews the relevant studies that have shown that exosomes play an important role in protective mechanisms against ischemic brain injury.

引用

页数：8

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