Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma

被引：11

作者：

Batelja-Vuletic, Lovorka ^{[1
]}

Tomasovic-Loncaric, Cedna ^{[2
]}

Ceppi, Marcello ^{[3
]}

Bruzzone, Marco ^{[3
]}

Fucic, Aleksandra ^{[4
]}

Krstanac, Karolina ^{[2
]}

Vucicevic, Vanja Boras ^{[5
]}

机构：

[1] Univ Zagreb, Med Sch, Zagreb 10000, Croatia

[2] Clin Hosp Ctr Dubrava, Zagreb 10000, Croatia

[3] IRCCS Osped Policlin San Martino, I-16124 Genoa, Italy

[4] Inst Med Res & Occupat Hlth, Zagreb 10000, Croatia

[5] Univ Zagreb, Sch Dent, Zagreb 10000, Croatia

来源：

LIFE-BASEL | 2021年 / 11卷 / 04期

关键词：

oral squamous cell carcinoma; androgen receptor; VEGF; HIF-1; Ki67; MMP9;

D O I：

10.3390/life11040336

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy with low survival as it is very often diagnosed at an advanced stage, which is why the accurate profiling of the tumor is essential. The aim of this study was to, for the first time, compare in OSCC the frequency of AR, VEGF, MMP9, HiF1beta and Ki67 between the non-metastatic and metastatic disease. Materials and Methods: In the study, 96 non-metastatic and 91 metastatic OSCC patients were analysed for AR, VEGF, MMP9, HiF1beta and Ki67 levels by immunohistochemistry. Results: All of the tested biomarkers significantly differed between non-metastatic and metastatic disease. A significant association was found between >/=20% AR positive epithelium cells in cytoplasm, Ki67 and VEGF in cancer stroma. Ki67, HiF1beta, VEGF and MMP9 were significantly associated with TNM stages. Conclusion: Our results show for the first time an interplay between AR, VEGF, MMP9, HiF1beta and Ki67 in OSCC which may contribute to better diagnostics and therapy selection.

引用

页数：10

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