Effects of ENU dosage on mouse strains

被引：115

作者：

Justice, MJ ^{[1
]}

Carpenter, DA

Favor, J

Neuhauser-Klaus, A

de Angelis, MH

Soewarto, D

Moser, A

Cordes, S

Miller, D

Chapman, V

Weber, JS

Rinchik, EM

Hunsicker, PR

Russell, WL

Bode, VC

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Oak Ridge Natl Lab, Div Life Sci, Oak Ridge, TN 37831 USA

[3] GSF, Natl Res Ctr Environm & Hlth, Neuherberg, Germany

[4] Univ Wisconsin, Dept Human Oncol, Madison, WI 53792 USA

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[7] Kansas State Univ, Div Biol, Manhattan, KS 66706 USA

来源：

MAMMALIAN GENOME | 2000年 / 11卷 / 07期

关键词：

D O I：

10.1007/s003350010094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F-1 hybrids to ENU. The results show that most F-1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.

引用

页码：484 / 488

页数：5

共 24 条

[1] BODE VC, 1984, GENETICS, V108, P457
[2] THE MOUSE SEGMENTATION GENE KR ENCODES A NOVEL BASIC DOMAIN LEUCINE-ZIPPER TRANSCRIPTION FACTOR
CORDES, SP
BARSH, GS
[J]. CELL, 1994, 79 (06) : 1025 - 1034
[3] Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea
Davis, AP
Woychik, RP
Justice, MJ
[J]. MAMMALIAN GENOME, 1999, 10 (03) : 308 - 310
[4] Davis AP, 1998, GENETICS, V148, P7
[5] DOMINANT CATARACT MUTATIONS AND SPECIFIC-LOCUS MUTATIONS IN MICE INDUCED BY RADIATION OR ETHYLNITROSOUREA
EHLING, UH
FAVOR, J
KRATOCHVILOVA, J
NEUHAUSERKLAUS, A
[J]. MUTATION RESEARCH, 1982, 92 (1-2): : 181 - 192
[6] THE INDUCTION OF FORWARD AND REVERSE SPECIFIC-LOCUS MUTATIONS AND DOMINANT CATARACT MUTATIONS IN SPERMATOGONIA OF TREATED STRAIN DBA/2 MICE BY ETHYLNITROSOUREA
FAVOR, J
NEUHAUSERKLAUS, A
EHLING, UH
[J]. MUTATION RESEARCH, 1991, 249 (02): : 293 - 300
[7] The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea
Favor, J
NeuhauserKlaus, A
Ehling, UH
Wulff, A
vanZeeland, AA
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1997, 374 (02) : 193 - 199
[8] THE EFFECT OF DOSE FRACTIONATION ON THE FREQUENCY OF ETHYLNITROSOUREA-INDUCED DOMINANT CATARACT AND RECESSIVE SPECIFIC LOCUS MUTATIONS IN GERM-CELLS OF THE MOUSE
FAVOR, J
NEUHAUSERKLAUS, A
EHLING, UH
[J]. MUTATION RESEARCH, 1988, 198 (02): : 269 - 275
[9] DOSE-REPETITION INCREASES THE MUTAGENIC EFFECTIVENESS OF N-ETHYL-N-NITROSOUREA IN MOUSE SPERMATOGONIA
HITOTSUMACHI, S
CARPENTER, DA
RUSSELL, WL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) : 6619 - 6621
[10] ELECTROPHORETICALLY DETECTED GERMINAL MUTATIONS INDUCED IN THE MOUSE BY ETHYLNITROSOUREA
JOHNSON, FM
LEWIS, SE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05): : 3138 - 3141

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