Prognostic values of HE4 expression in patients with cancer: a meta-analysis

被引：16

作者：

Dai, Cong ^{[1
,2
]}

Zheng, Yi ^{[2
]}

Li, Yuanjie ^{[3
]}

Tian, Tian ^{[2
]}

Wang, Meng ^{[2
]}

Xu, Peng ^{[2
]}

Deng, Yujiao ^{[2
]}

Hao, Qian ^{[2
]}

Wu, Ying ^{[2
]}

Zhai, Zhen ^{[2
]}

Dai, Zhijun ^{[2
]}

Lyu, Jun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Clin Res Ctr, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, 157 Xiwu Rd, Xian 710004, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Xian 710061, Shaanxi, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2018年 / 10卷

关键词：

HE4; cancer; prognosis; meta-analysis; EPIDIDYMIS PROTEIN 4; EPITHELIAL OVARIAN-CANCER; CELL LUNG-CANCER; SERUM HE-4; ENDOMETRIAL CANCER; COLORECTAL-CANCER; TISSUE EXPRESSION; TUMOR-MARKER; SURVIVAL; CARCINOMA;

D O I：

10.2147/CMAR.S178345

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To evaluate the prognostic impact of HE4 expression in patients with cancer. Materials and methods: We searched the PubMed, Web of Science, Chinese National Knowledge Infrastructure and WangFang databases for publications concerning HE4 expression in patients with cancer. The correlation of HE4 expression level with overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) was analyzed. Results: In this meta-analysis, 29 studies, with a total of 4,235 patients, were included. Our results showed that HE4 expression was significantly associated with poorer OS (hazard ratio [HR] =2.15, 95% confidence interval [CI] =1.77-2.62, P<0.001). Further subgroup analysis found that this correlation was not affected by race (White: HR =1.92, 95% CI =1.53-2.39, P<0.001; Asian: HR =2.62, 95% CI =2.06-3.35, P<0.001) or tumor types (endometrial cancer: HR =2.91, 95% CI =1.86-4.53, P<0.001; ovarian cancer: HR =1.82, 95% CI = 1.50-2.22, P<0.001; lung cancer: HR =2.31, 95% CI =1.54-3.47, P<0.001). Our meta-analysis showed that HE4 overexpression was significantly associated with DFS (HR =2.50, 95% CI =1.86-3.37, P<0.001) and PFS (HR =1.27, 95% CI =1.11-1.45, P=0.001). Conclusion: These results suggest that expression of HE4 was associated with a worse prognosis in patients with cancer. HE4 is a potential novel prognostic factor in patients with cancer.

引用

页码：4491 / 4500

页数：10

共 48 条

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