Vincristine-induced paralytic ileus during induction therapy of treatment protocols for acute lymphoblastic leukemia in adult patients

被引：13

作者：

Yasu, Takeo ^{[1
]}

Ohno, Nobuhiro ^{[2
]}

Kawamata, Toyotaka ^{[2
]}

Kurokawa, Yosuke ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Res Hosp, Dept Pharm, Tokyo 1088639, Japan

[2] Univ Tokyo, Inst Med Sci, Res Hosp, Dept Hematol Oncol, Tokyo 1088639, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2016年 / 54卷 / 06期

关键词：

vincristine; paralytic ileus; itraconazole; drug interaction; acute lymphoblastic leukemia; PHASE-II;

D O I：

10.5414/CP202584

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vincristine (VCR) is an important drug used in the treatment of acute lymphoblastic leukemia (ALL). VCR-induced neurotoxicity can manifest as peripheral neuropathy, constipation, or paralytic ileus. While there are some case reports describing VCR-induced paralytic ileus (VIPI) in pediatric ALL, there are fewer publication on adult ALL patients. Therefore, we retrospectively investigated VIPI during induction therapy of treatment protocols for ALL in 19 adult patients. The incidence of VIPI was 32%. VIPI was significantly increased in patients receiving concomitant itraconazole (ITCZ) (p = 0.04). We recommend avoidance of the combination of VCR and ITCZ.

引用

页码：471 / 473

页数：3

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