[RhCp*Cl2]2-Catalyzed Directed N-Boc Amidation of Arenes "on Water"

被引：56

作者：

Ali, Md Ashif ^{[1
]}

Yao, Xiayin ^{[1
]}

Sun, Hao ^{[1
]}

Lu, Hongjian ^{[1
]}

机构：

[1] Nanjing Univ, Inst Chem BioMed Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 06期

基金：

中国国家自然科学基金;

关键词：

C-H AMIDATION; CATALYZED DIRECT AMINATION; DIELS-ALDER REACTIONS; ORGANIC-REACTIONS; CYTOSTATIC ACTIVITY; EFFICIENT; BONDS; ACCELERATION; AZIDES; CYCLOADDITION;

D O I：

10.1021/acs.orglett.5b00392

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(III) catalysis on water is effective for directed C-H amidation of arenes. The catalytic process is promoted by OH groups present on the hydrophobic water surface and is inefficient in all (most) common organic solvents investigated so far. In the presence of easily prepared tert-butyl 2,4-dinitrophenoxycarbamate, a new and stable nitrene source, the on water reaction can efficiently provide the desired N-Boc-aminated products with good functional group tolerance.

引用

页码：1513 / 1516

页数：4

共 61 条

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[Anonymous], SCIENCE

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