Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid

被引:188
|
作者
Kawashita, M [1 ]
Nakao, M
Minoda, M
Kim, HM
Beppu, T
Miyamoto, T
Kokubo, T
Nakamura, T
机构
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 6068501, Japan
[2] Kyoto Inst Technol, Fac Engn & Design, Dept Chem & Mat Technol, Kyoto 6068585, Japan
[3] Yonsei Univ, Dept Ceram Engn, Seoul 120749, South Korea
[4] Matsue Natl Coll Technol, Dept Elect Engn, Matsue, Shimane 6908518, Japan
[5] Kyoto Univ, Grad Sch Med, Dept Orthopaed Surg, Sakyo Ku, Kyoto 6068507, Japan
关键词
carboxyl group; polymer; apatite; composite; simulated body fluid; biomimetic method;
D O I
10.1016/S0142-9612(03)00050-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Carboxymethylated chitin, gellan gum, and curdlan gels were soaked in a simulated body fluid (SBF) having ion concentrations nearly equal to those of human blood plasma. Some of the gels had been soaked in a saturated Ca(OH)(2) solution, while others had not. The carboxymethylated chitin and gellan gum gels have carboxyl groups, while the curdlan gel has hydroxyl groups. None of the gels formed apatite on their surfaces in the SBF when they had not been subjected to the Ca(OH)(2) treatment, whereas the carboxymethylated chitin and gellan gum gels formed apatite on their surfaces when they had been subjected to the Ca(OH)(2) treatment. The curdlan gel did not form an apatite deposit even after the Ca(OH)(2) treatment. Apatite formation on the carboxymethylated chitin and gellan gum gels was attributed to the catalytic effect of their carboxyl groups for apatite nucleation, and acceleration of apatite nucleation from released Ca2+ ions. This result provides a guiding principle for obtaining apatite-organic polymer fiber composites. This composite is expected to have an analogous structure to that of natural bone. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码:2477 / 2484
页数:8
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