Long-term Follow-up in Cancer Prevention Trials (It Ain't Over 'Til It's Over)

被引：19

作者：

Cuzick, Jack ^{[1
]}

机构：

[1] Univ London, Wolfson Inst Prevent Med, Canc Res UK Ctr Epidemiol Math & Stat, London EC1M 6BQ, England

来源：

CANCER PREVENTION RESEARCH | 2010年 / 3卷 / 06期

关键词：

BREAST-CANCER; PARTICLE VACCINE; TAMOXIFEN; WOMEN;

D O I：

10.1158/1940-6207.CAPR-10-0096

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The update of the Study of Tamoxifen and Raloxifene by Vogel et al. (beginning on p. 696 in this issue of the journal) highlights the overall importance of long-term follow-up of cancer prevention trials, which need long follow-up to fully determine agent risks and benefits. Biomarkers (e.g., reduced cervical intraepithelial neoplasia 3 after human papillomavirus vaccination) can provide an early indication of efficacy but almost never replace the cancer end point in determining the ultimate utility of an agent. Long follow-up is also important to fully determine preventive benefit, as illustrated by the tamoxifen trials, where only 60% as many treated women were needed to prevent one cancer at 10 years as at approximately 5 years, the time of the early reports. Cancer Prev Res; 3(6); 689-91. (C) 2010 AACR.

引用

页码：689 / 691

页数：3

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