Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration

被引：149

作者：

Li, J

Milne, RW ^{[1
]}

Nation, RL

Turnidge, JD

Smeaton, TC

Coulthard, K

机构：

[1] Univ S Australia, Sch Pharmaceut Mol & Biomed Sci, Pharmaceut Res Ctr, Adelaide, SA 5000, Australia

[2] Womens & Childrens Hosp, Dept Pharm, Adelaide, SA, Australia

[3] Womens & Childrens Hosp, Dept Microbiol & Infect Dis, Adelaide, SA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 05期

关键词：

D O I：

10.1128/AAC.47.5.1766-1770.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

引用

页码：1766 / 1770

页数：5

共 29 条

[1]

ABE M, 1976, CHEMOTHERAPY, V24, P1592

[2] PHARMACOLOGIC AND TOXICOLOGIC STUDIES WITH POLYMYXINS .2. COMPARATIVE PHARMACOLOGIC STUDIES OF SULFATE AND METHANESULFONATE SALTS OF POLYMYXIN-B AND COLISTIN IN DOGS [J].