The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19

被引：20

作者：

Iliadi, Valeria ^{[1
]}

Konstantinidou, Ina ^{[2
]}

Aftzoglou, Konstantina ^{[3
]}

Iliadis, Sergios ^{[1
]}

Konstantinidis, Theocharis G. ^{[4
]}

Tsigalou, Christina ^{[5
]}

机构：

[1] Izhevsk State Med Acad, Sch Med, Kommunarov St 281, Izhevsk 426034, Russia

[2] Univ Patras, Sch Med, Rion 26504, Patra, Greece

[3] Comenius Univ, Sch Med, Spitalska 24, Bratislava 81372, Slovakia

[4] Univ Gen Hosp Alexandroupolis Dragana Campus, Ctr Blood Transfus, Alexandroupolis 68100, Greece

[5] Democritus Univ Thrace, Microbiol Lab, Dragana Campus, Alexandroupolis 68100, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 10期

基金：

英国科研创新办公室;

关键词：

COVID-19; SARS CoV-2; NETs; immunothrombosis; EXTRACELLULAR TRAP FORMATION; CRITICALLY-ILL PATIENTS; TISSUE FACTOR; SINGLE-CENTER; NET FORMATION; WHOLE-BLOOD; ELASTASE; ACTIVATION; COLCHICINE; INFECTION;

D O I：

10.3390/ijms22105368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have shown that COVID-19 leads to thrombotic complications, which have been associated with high morbidity and mortality rates. Neutrophils are the largest population of white blood cells and play a pivotal role in innate immunity. During an infection, neutrophils migrate from circulation to the infection site, contributing to killing pathogens. This mechanism is regulated by chemokines such as IL-8. Moreover, it was shown that neutrophils play an important role in thromboinflammation. Through a diverse repertoire of mechanisms, neutrophils, apart from directly killing pathogens, are able to activate the formation of thrombi. In COVID-19 patients, neutrophil activation promotes neutrophil extracellular trap (NET) formation, platelet aggregation, and cell damage. Furthermore, neutrophils participate in the pathogenesis of endothelitis. Overall, this review summarizes recent progress in research on the pathogenesis of COVID-19, highlighting the role of the prothrombotic action of neutrophils in NET formation.

引用

页数：17

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