Pathogenesis of Necrotizing Enterocolitis Modeling the Innate Immune Response

被引：146

作者：

Tanner, Scott M. ^{[1
,2
]}

Berryhill, Taylor F. ^{[1
]}

Ellenburg, James L. ^{[1
]}

Jilling, Tamas ^{[3
]}

Cleveland, Dava S. ^{[4
]}

Lorenz, Robin G. ^{[2
]}

Martin, Colin A. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat Surg, Birmingham, AL 35233 USA

[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Pathol, Div Neonatol, Birmingham, AL 35294 USA

[4] Childrens Hosp Alabama, Dept Pediat Pathol, Birmingham, AL USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2015年 / 185卷 / 01期

关键词：

EPIDERMAL-GROWTH-FACTOR; NEONATAL-RAT MODEL; PLATELET-ACTIVATING-FACTOR; PRETERM HUMAN-MILK; PANETH CELLS; SMALL-INTESTINE; CRONOBACTER-SAKAZAKII; NEWBORN-INFANTS; GENE-EXPRESSION; DENDRITIC CELLS;

D O I：

10.1016/j.ajpath.2014.08.028

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review provides an updated summary of the components of the innate immune system involved in NEC pathogenesis. In addition, we evaluate the animal models that have been used to study NEC with regard to the involvement of innate immune factors and histopathological changes as compared to those seen in infants with NEC. Finally, we discuss new approaches to studying NEC, including mathematical models of intestinal injury and the use of humanized mice.

引用

页码：4 / 16

页数：13

共 103 条

[1] Paneth cells as a site of origin for intestinal inflammation [J].

Adolph, Timon E. ;

Tomczak, Michal F. ;

Niederreiter, Lukas ;

Ko, Hyun-Jeong ;

Boeck, Janne ;

Martinez-Naves, Eduardo ;

Glickman, Jonathan N. ;

Tschurtschenthaler, Markus ;

Hartwig, John ;

Hosomi, Shuhei ;

Flak, Magdalena B. ;

Cusick, Jennifer L. ;

Kohno, Kenji ;

Iwawaki, Takao ;

Billmann-Born, Susanne ;

Raine, Tim ;

Bharti, Richa ;

Lucius, Ralph ;

Kweon, Mi-Na ;

Marciniak, Stefan J. ;

Choi, Augustine ;

Hagen, Susan J. ;

Schreiber, Stefan ;

Rosenstiel, Philip ;

Kaser, Arthur ;

Blumberg, Richard S. .

NATURE, 2013, 503 (7475) :272-+

[2] Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis* [J].

Afrazi, Amin ;

Branca, Maria F. ;

Sodhi, Chhinder P. ;

Good, Misty ;

Yamaguchi, Yukihiro ;

Egan, Charlotte E. ;

Lu, Peng ;

Jia, Hongpeng ;

Shaffiey, Shahab ;

Lin, Joyce ;

Ma, Congrong ;

Vincent, Garrett ;

Prindle, Thomas, Jr. ;

Weyandt, Samantha ;

Neal, Matthew D. ;

Ozolek, John A. ;

Wiersch, John ;

Tschurtschenthaler, Markus ;

Shiota, Chiyo ;

Gittes, George K. ;

Billiar, Timothy R. ;

Mollen, Kevin ;

Kaser, Arthur ;

Blumberg, Richard ;

Hackam, David J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (14) :9584-9599

[3] Preparation and handling of powdered infant formula: A commentary by the ESPGHAN committee on nutrition [J].

Agostoni, C ;

Axelsson, T ;

Goulet, T ;

Koletzko, B ;

Michaelsen, JF ;

Puntis, JWL ;

Rigo, J ;

Shamir, T ;

Szajewska, H ;

Turck, D ;

Vandenplas, J ;

Weaver, LT .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2004, 39 (04) :320-322

[4] Using a Mathematical Model to Analyze the Role of Probiotics and Inflammation in Necrotizing Enterocolitis [J].

Arciero, Julia C. ;

Ermentrout, G. Bard ;

Upperman, Jeffrey S. ;

Vodovotz, Yoram ;

Rubin, Jonathan E. .

PLOS ONE, 2010, 5 (04)

[5] PATHOLOGY OF NEONATAL NECROTIZING ENTEROCOLITIS - A 10-YEAR EXPERIENCE [J].

BALLANCE, WA ;

DAHMS, BB ;

SHENKER, N ;

KLIEGMAN, RM .

JOURNAL OF PEDIATRICS, 1990, 117 (01) :S6-S13

[6] A three-dimensional mathematical and computational model of necrotizing enterocolitis [J].

Barber, Jared ;

Tronzo, Mark ;

Horvat, C. Harold ;

Clermont, Gilles ;

Upperman, Jeffrey ;

Vodovotz, Yoram ;

Yotov, Ivan .

JOURNAL OF THEORETICAL BIOLOGY, 2013, 322 :17-32

[7] IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis [J].

Baregamian, Naira ;

Song, Jun ;

Jeschke, Marc G. ;

Evers, B. Mark ;

Chung, Dai H. .

JOURNAL OF SURGICAL RESEARCH, 2006, 136 (01) :31-37

[8] Comprehensive Evaluation of 11 Cytokines in Premature Infants with Surgical Necrotizing Enterocolitis [J].

Benkoe, Thomas ;

Baumann, Suzann ;

Weninger, Manfred ;

Pones, Mario ;

Reck, Carlos ;

Rebhandl, Winfried ;

Oehler, Rudolf .

PLOS ONE, 2013, 8 (03)

[9] Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis [J].

Bergmann, Kelly R. ;

Liu, Shirley X. L. ;

Tian, Runlan ;

Kushnir, Anna ;

Turner, Jerrold R. ;

Li, Hong-Lin ;

Chou, Pauline M. ;

Weber, Christopher R. ;

De Plaen, Isabelle G. .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (05) :1595-1606

[10] Nature of bacterial colonization influences transcription of mucin genes in mice during the first week of life [J].

Bergström A. ;

Kristensen M.B. ;

Bahl M.I. ;

Metzdorff S.B. ;

Fink L.N. ;

Frøkiær H. ;

Licht T.R. .

BMC Research Notes, 5 (1)

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