Pathogenesis of Necrotizing Enterocolitis Modeling the Innate Immune Response

被引：145

作者：

Tanner, Scott M. ^{[1
,2
]}

Berryhill, Taylor F. ^{[1
]}

Ellenburg, James L. ^{[1
]}

Jilling, Tamas ^{[3
]}

Cleveland, Dava S. ^{[4
]}

Lorenz, Robin G. ^{[2
]}

Martin, Colin A. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat Surg, Birmingham, AL 35233 USA

[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Pathol, Div Neonatol, Birmingham, AL 35294 USA

[4] Childrens Hosp Alabama, Dept Pediat Pathol, Birmingham, AL USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2015年 / 185卷 / 01期

关键词：

EPIDERMAL-GROWTH-FACTOR; NEONATAL-RAT MODEL; PLATELET-ACTIVATING-FACTOR; PRETERM HUMAN-MILK; PANETH CELLS; SMALL-INTESTINE; CRONOBACTER-SAKAZAKII; NEWBORN-INFANTS; GENE-EXPRESSION; DENDRITIC CELLS;

D O I：

10.1016/j.ajpath.2014.08.028

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review provides an updated summary of the components of the innate immune system involved in NEC pathogenesis. In addition, we evaluate the animal models that have been used to study NEC with regard to the involvement of innate immune factors and histopathological changes as compared to those seen in infants with NEC. Finally, we discuss new approaches to studying NEC, including mathematical models of intestinal injury and the use of humanized mice.

引用

页码：4 / 16

页数：13

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