Animal models for SARS-CoV-2

被引：50

作者：

Lee, Chung-Young ^{[1
]}

Lowen, Anice C. ^{[1
,2
]}

机构：

[1] Emory Univ, Dept Microbiol & Immunol, Sch Med, Atlanta, GA 30322 USA

[2] Emory UGA Ctr Excellence Influenza Res & Surveill, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN VIROLOGY | 2021年 / 48卷

关键词：

ACUTE RESPIRATORY SYNDROME; SYNDROME CORONAVIRUS INFECTION; SYRIAN-HAMSTER; AFRICAN-GREEN; SARS-COV; COVID-19; VACCINE; POTENT; TRACT; MICE;

D O I：

10.1016/j.coviro.2021.03.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since its first detection in December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly spread worldwide, resulting in over 79.2 million documented cases in one year. Lack of pre-existing immunity against this newly emerging virus has pushed the urgent development of anti-viral therapeutics and vaccines to reduce the spread of the virus and alleviate disease. Appropriate animal models recapitulating the pathogenesis of and host responses to SARS-CoV-2 infection in humans have and will continue to accelerate this development process. Several animal models including mice, hamsters, ferrets, and non-human primates have been evaluated and actively applied in preclinical studies. However, since each animal model has unique features, it is necessary to weigh the strengths and weaknesses of each according to the goals of the study. Here, we summarize the key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.

引用

页码：73 / 81

页数：9

共 101 条

[1] Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial [J].

Alberer, Martin ;

Gnad-Vogt, Ulrike ;

Hong, Henoch Sangjoon ;

Mehr, Keyvan Tadjalli ;

Backert, Linus ;

Finak, Greg ;

Gottardo, Raphael ;

Bica, Mihai Alexandru ;

Garofano, Aurelio ;

Koch, Sven Dominik ;

Fotin-Mleczek, Mariola ;

Hoerr, Ingmar ;

Clemens, Ralf ;

von Sonnenburg, Frank .

LANCET, 2017, 390 (10101) :1511-1520

[2] A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection [J].

Alsoussi, Wafaa B. ;

Turner, Jackson S. ;

Case, James B. ;

Zhao, Haiyan ;

Schmitz, Aaron J. ;

Zhou, Julian Q. ;

Chen, Rita E. ;

Lei, Tingting ;

Rizk, Amena A. ;

McIntire, Katherine M. ;

Winkler, Emma S. ;

Fox, Julie M. ;

Kafai, Natasha M. ;

Thackray, Larissa B. ;

Hassan, Ahmed O. ;

Amanat, Fatima ;

Krammer, Florian ;

Watson, Corey T. ;

Kleinstein, Steven H. ;

Fremont, Daved H. ;

Diamond, Michael S. ;

Ellebedy, Ali H. .

JOURNAL OF IMMUNOLOGY, 2020, 205 (04) :915-922

[3] Coronavirus outbreak in Nigeria: Burden and socio-medical response during the first 100 days [J].

Amzat, Jimoh ;

Aminu, Kafayat ;

Kolo, Victor, I ;

Akinyele, Ayodele A. ;

Ogundairo, Janet A. ;

Danjibo, Maryann C. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 98 :218-224

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice [J].

Bao, Linlin ;

Deng, Wei ;

Huang, Baoying ;

Gao, Hong ;

Liu, Jiangning ;

Ren, Lili ;

Wei, Qiang ;

Yu, Pin ;

Xu, Yanfeng ;

Qi, Feifei ;

Qu, Yajin ;

Li, Fengdi ;

Lv, Qi ;

Wang, Wenling ;

Xue, Jing ;

Gong, Shuran ;

Liu, Mingya ;

Wang, Guanpeng ;

Wang, Shunyi ;

Song, Zhiqi ;

Zhao, Linna ;

Liu, Peipei ;

Zhao, Li ;

Ye, Fei ;

Wang, Huijuan ;

Zhou, Weimin ;

Zhu, Na ;

Zhen, Wei ;

Yu, Haisheng ;

Zhang, Xiaojuan ;

Guo, Li ;

Chen, Lan ;

Wang, Conghui ;

Wang, Ying ;

Wang, Xinming ;

Xiao, Yan ;

Sun, Qiangming ;

Liu, Hongqi ;

Zhu, Fanli ;

Ma, Chunxia ;

Yan, Lingmei ;

Yang, Mengli ;

Han, Jun ;

Xu, Wenbo ;

Tan, Wenjie ;

Peng, Xiaozhong ;

Jin, Qi ;

Wu, Guizhen ;

Qin, Chuan .

NATURE, 2020, 583 (7818) :830-+

[6] A brief review of socio-economic and environmental impact of Covid-19 [J].

Bashir, Muhammad Farhan ;

Ma, Benjiang ;

Shahzad, Luqman .

AIR QUALITY ATMOSPHERE AND HEALTH, 2020, 13 (12) :1403-1409

[7] REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters [J].

Baum, Alina ;

Ajithdoss, Dharani ;

Copin, Richard ;

Zhou, Anbo ;

Lanza, Kathryn ;

Negron, Nicole ;

Ni, Min ;

Wei, Yi ;

Mohammadi, Kusha ;

Musser, Bret ;

Atwal, Gurinder S. ;

Oyejide, Adelekan ;

Goez-Gazi, Yenny ;

Dutton, John ;

Clemmons, Elizabeth ;

Staples, Hilary M. ;

Bartley, Carmen ;

Klaffke, Benjamin ;

Alfson, Kendra ;

Gazi, Michal ;

Gonzalez, Olga ;

Dick, Edward, Jr. ;

Carrion, Ricardo, Jr. ;

Pessaint, Laurent ;

Porto, Maciel ;

Cook, Anthony ;

Brown, Renita ;

Ali, Vaneesha ;

Greenhouse, Jack ;

Taylor, Tammy ;

Andersen, Hanne ;

Lewis, Mark G. ;

Stahl, Neil ;

Murphy, Andrew J. ;

Yancopoulos, George D. ;

Kyratsous, Christos A. .

SCIENCE, 2020, 370 (6520) :1110-+

[8] Acute Respiratory Distress in Aged, SARS-CoV-2-Infected African Green Monkeys but Not Rhesus Macaques [J].

Blair, Robert V. ;

Vaccari, Monica ;

Doyle-Meyers, Lara A. ;

Roy, Chad J. ;

Russell-Lodrigue, Kasi ;

Fahlberg, Marissa ;

Monjure, Chris J. ;

Bedding, Brandon ;

Plante, Kenneth S. ;

Plante, Jessica A. ;

Weaver, Scott C. ;

Qin, Xuebin ;

Midkiff, Cecily C. ;

Lehmicke, Gabrielle ;

Golden, Nadia ;

Threeton, Breanna ;

Penney, Toni ;

Allers, Carolina ;

Barnes, Mary B. ;

Pattison, Melissa ;

Datta, Prasun K. ;

Maness, Nicholas J. ;

Bimbaum, Angela ;

Fischer, Tracy ;

Bohm, Rudolf P. ;

Rappaport, Jay .

AMERICAN JOURNAL OF PATHOLOGY, 2021, 191 (02) :274-282

[9] Animal Models for Influenza Virus Pathogenesis and Transmission [J].

Bouvier, Nicole M. ;

Lowen, Anice C. .

VIRUSES-BASEL, 2010, 2 (08) :1530-1563

[10] A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].

Chan, Jasper Fuk-Woo ;

Yuan, Shuofeng ;

Kok, Kin-Hang ;

To, Kelvin Kai-Wang ;

Chu, Hin ;

Yang, Jin ;

Xing, Fanfan ;

Liu, Jieling ;

Yip, Cyril Chik-Yan ;

Poon, Rosana Wing-Shan ;

Tsoi, Hoi-Wah ;

Lo, Simon Kam-Fai ;

Chan, Kwok-Hung ;

Poon, Vincent Kwok-Man ;

Chan, Wan-Mui ;

Ip, Jonathan Daniel ;

Cai, Jian-Piao ;

Cheng, Vincent Chi-Chung ;

Chen, Honglin ;

Hui, Christopher Kim-Ming ;

Yuen, Kwok-Yung .

LANCET, 2020, 395 (10223) :514-523

← 1 2 3 4 5 6 7 8 9 10 →