The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

被引：20

作者：

Bailey, Jessica N. Cooke ^{[1
,2
]}

Hoffman, Joshua D. ^{[3
]}

Sardell, Rebecca J. ^{[4
]}

Scott, William K. ^{[4
]}

Pericak-Vance, Margaret A. ^{[4
]}

Haines, Jonathan L. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Inst Computat Biol, Cleveland, OH 44106 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[4] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 03期

关键词：

age-related macular degeneration (AMD); genetics; risk score; GENOMEWIDE-SCAN; SUSCEPTIBILITY LOCI; MACULOPATHY; CFH; RARE; ASSOCIATION; PROGRESSION; PREDICTION; VARIANT; ARMS2;

D O I：

10.3390/jcm5030031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.

引用

页数：13

共 50 条

[21] Interactions among different genetic loci in age-related macular degeneration
Bonyadi, Mortaza
Bonyadi, Mohammad Hossein Jabbarpoor
Yaseri, Mehdi
Soheilian, Masoud
[J]. OPHTHALMIC GENETICS, 2018, 39 (02) : 189 - 193
[22] Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Chen, Li Jia
[J]. ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY, 2020, 9 (02): : 104 - 109
[23] Genetic association study of age-related macular degeneration in the Spanish population
Brion, Maria
Sanchez-Salorio, Manuel
Corton, Marta
de la Fuente, Maria
Pazos, Belen
Othman, Mohammad
Swaroop, Anand
Abecasis, Goncalo
Sobrino, Beatriz
Carracedo, Angel
[J]. ACTA OPHTHALMOLOGICA, 2011, 89 (01) : E12 - E22
[24] Age-Related Macular Degeneration
Thomas, Catherine J.
Mirza, Rukhsana G.
Gill, Manjot K.
[J]. MEDICAL CLINICS OF NORTH AMERICA, 2021, 105 (03) : 473 - 491
[25] Overweight, Obesity, and Risk of Age-Related Macular Degeneration
Zhang, Qian-Yu
Tie, Li-Jun
Wu, Shan-Shan
Lv, Pei-Lin
Huang, Hong-Wei
Wang, Wei-Qing
Wang, Hui
Ma, Le
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (03) : 1276 - 1283
[26] Modifiable risk factors for age-related macular degeneration
de Almeida Torres, Rogil Jose
Maia, Mauricio
Muccioli, Cristina
Winter, Guilherme
de Souza, Greyce Kelly
Pasqualotto, Luca Rodrigo
Luchini, Andrea
Precoma, Dalton Bertolim
[J]. ARQUIVOS BRASILEIROS DE OFTALMOLOGIA, 2009, 72 (03) : 406 - 412
[27] Treatment of dry age-related macular degeneration: A review
Girgis, Shenouda
Lee, Lawrence R.
[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2023, 51 (08) : 835 - 852
[28] Age-related Macular Degeneration (AMD): A Review on its Epidemiology and Risk Factors
Salimiaghdam, Nasim
Riazi-Esfahani, Mohammad
Fukuhara, Paula S.
Schneider, Kevin
Kenney, M. Cristina
[J]. OPEN OPHTHALMOLOGY JOURNAL, 2019, 13 : 90 - 99
[29] Statin Use and the Incidence of Advanced Age-related Macular Degeneration in the Complications of Age-related Macular Degeneration Prevention Trial
Maguire, Maureen G.
Ying, Gui-shuang
McCannel, Colin A.
Liu, Chengcheng
Dai, Yang
[J]. OPHTHALMOLOGY, 2009, 116 (12) : 2381 - 2385
[30] Genetic Risk Score Predicts of Severity of Age-related Macular Degeneration
Haines, Jonathan
Agarwal, Anita
Bailey, Jessica Cooke
Hoffman, Joshua
McGrath, J. Allie
Olson, Lana
Kovach, Jaclyn
Schwartz, Stephen
Scott, William
Pericak-Vance, Margaret
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)

← 1 2 3 4 5 →