The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

被引：20

作者：

Bailey, Jessica N. Cooke ^{[1
,2
]}

Hoffman, Joshua D. ^{[3
]}

Sardell, Rebecca J. ^{[4
]}

Scott, William K. ^{[4
]}

Pericak-Vance, Margaret A. ^{[4
]}

Haines, Jonathan L. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Inst Computat Biol, Cleveland, OH 44106 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[4] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 03期

关键词：

age-related macular degeneration (AMD); genetics; risk score; GENOMEWIDE-SCAN; SUSCEPTIBILITY LOCI; MACULOPATHY; CFH; RARE; ASSOCIATION; PROGRESSION; PREDICTION; VARIANT; ARMS2;

D O I：

10.3390/jcm5030031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.

引用

页数：13

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