CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features

被引：107

作者：

Karube, Kennosuke

Guo, Ying

Suzumiya, Junji

Sugita, Yasuo

Nomura, Yuko

Yamamoto, Kohei

Shimizu, Kei

Yoshida, Shirou

Komatani, Hideki

Takeshita, Morishige

Kikuchi, Masahiro

Nakamura, Naoya

Takasu, Osamu

Arakawa, Fumiko

Tagawa, Hiroyuki

Seto, Masao

Ohshima, Koichi

机构：

[1] Kurume Univ, Sch Med, Dept Pathol, Kurume, Fukuoka 8300011, Japan

[2] Fourth Mil Med Univ, Xijing Hosp, State Key Lab Canc Biol, Dept Pathol, Xian, Shannxi, Peoples R China

[3] Fukuoka Univ, Sch Med, Dept Internal Med, Fukuoka 81401, Japan

[4] Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 81401, Japan

[5] Fukuoka Univ, Sch Med, Dept Pediat, Fukuoka 81401, Japan

[6] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 25911, Japan

[7] Aichi Canc Ctr Inst, Div Mol Med, Nagoya, Aichi, Japan

[8] Aichi Canc Ctr Inst, Div Hematol & Cell Therapy, Nagoya, Aichi, Japan

来源：

BLOOD | 2007年 / 109卷 / 07期

关键词：

D O I：

10.1182/blood-2006-09-045989

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10(-)MUM1(+) with 119 typical CD10(+)MUM1(-) FLs. All CD10(-)MUM1(+) FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10(+)MUM1(-) typical FLs (67.0 versus 58.7 years, P <.01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P <.001), diffuse proliferation (59% vs 19%, P <.001), and lacked BCL2/IGH translocation (5% versus 92.5%, P <.001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10(-)MUM1(+) FL is different from typical FL with respect to biologic and clinical features.

引用

页码：3076 / 3079

页数：4

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