Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis

被引：101
作者：
Shimizu, C
Hasegawa, T
Tani, Y
Takahashi, F
Takeuchi, M
Watanabe, T
Ando, M
Katsumata, N
Fujiwara, Y
机构：
[1] Natl Canc Ctr, Dept Med Oncol, Tokyo, Japan
[2] Natl Canc Ctr, Dept Pathol, Tokyo, Japan
[3] Kitasato Univ, Dept Clin Biostat, Sagamihara, Kanagawa, Japan
来源：
HUMAN PATHOLOGY | 2004年 / 35卷 / 12期
关键词：
insulin-like growth factor 1 receptor; immunohistochemistry; primary breast cancer; prognostic marker;
D O I：
10.1016/j.humpath.2004.09.005
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Insulin-like growth factor-1 receptor (IGF-1R) has been implicated in regulation in tumor growth. The results of previous studies performed by radioimmunoassay are conflicting, and the prognostic significance of IGF-1R expression in primary breast cancer is still controversial. IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody. The clinicopathologic variables and 5-year disease-free survival were studied, and their correlations between IGF-1R expressions were investigated. IGF-1R overexpression was observed in 43.8% of tumors. IGF-1R overexpression had no correlation with prognosis or with other clinicopathologic parameters, such as age, tumor size, nodal status, histologic grade, hormone receptor status, and human epidermal growth factor 2 status. Though its prognostic value in breast cancer is limited, immunohistochemical evaluation of IGF-1R by using this monoclonal antibody may be useful in translational research using archived material. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1537 / 1542
页数：6
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