Suicide and suicide risk

被引:596
作者
Turecki, Gustavo [1 ]
Brent, David A. [2 ]
Gunnell, David [3 ,4 ]
O'Connor, Rory C. [5 ]
Oquendo, Maria A. [6 ]
Pirkis, Jane [7 ]
Stanley, Barbara H. [8 ]
机构
[1] McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, McGill Grp Suicide Studies, Montreal, PQ, Canada
[2] Western Psychiat Inst & Clin, Pittsburgh, PA USA
[3] Univ Hosp Bristol NHS Fdn Trust, Natl Inst Hlth Res Biomed Res Ctr, Bristol, Avon, England
[4] Univ Bristol, Dept Populat Hlth Sci, Bristol, Avon, England
[5] Univ Glasgow, Inst Hlth & Wellbeing, Suicidal Behav Res Lab, Glasgow, Lanark, Scotland
[6] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[7] Univ Melbourne, Ctr Mental Hlth, Melbourne, Vic, Australia
[8] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA
关键词
RANDOMIZED CONTROLLED-TRIAL; MAJOR DEPRESSIVE DISORDER; EMISSION-TOMOGRAPHY QUANTIFICATION; DIALECTICAL BEHAVIOR-THERAPY; BDNF PROMOTER METHYLATION; EARLY-LIFE ADVERSITY; QUALITY-OF-LIFE; SELF-HARM; GENE-EXPRESSION; DOUBLE-BLIND;
D O I
10.1038/s41572-019-0121-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although recent years have seen large decreases in the overall global rate of suicide fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to present key challenges for public policy and health services, with increasing suicide deaths in some countries such as the USA. The development of suicide risk is complex, involving contributions from biological (including genetics), psychological (such as certain personality traits), clinical (such as comorbid psychiatric illness), social and environmental factors. The involvement of multiple risk factors in conveying risk of suicide means that determining an individual's risk of suicide is challenging. Improving risk assessment, for example, by using computer testing and genetic screening, is an area of ongoing research. Prevention is key to reduce the number of suicide deaths and prevention efforts include universal, selective and indicated interventions, although these interventions are often delivered in combination. These interventions, combined with psychological (such as cognitive behavioural therapy, caring contacts and safety planning) and pharmacological treatments (for example, clozapine and ketamine) along with coordinated social and public health initiatives, should continue to improve the management of individuals who are suicidal and decrease suicide-associated morbidity.
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页数:22
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