Effect of cefodizime on peritoneal mononuclear- and polymorphonuclear-cell chemotaxis

被引：0

作者：

Üstün, H ^{[1
]}

Ersoy, FF ^{[1
]}

Sezer, T ^{[1
]}

Özcan, S ^{[1
]}

Bozcuk, H ^{[1
]}

Yegin, O ^{[1
]}

Balci, M ^{[1
]}

Süleymanlar, G ^{[1
]}

Yakupoglu, G ^{[1
]}

机构：

[1] Akdeniz Univ, Sch Med, Dept Med, Antalya, Turkey

来源：

ADVANCES IN PERITONEAL DIALYSIS/1998, VOL 14 | 1998年 / 14卷

关键词：

cefodizime; peritonitis; chemotaxis;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, a third-generation cephalosporin with proposed immunomodulatory properties, cefodizime, was investigated to see if it has any effect on the chemotactic activity of human peritoneal monocyte and polymorphonuclear cell populations ex vivo. Ten continuous ambulatory peritoneal dialysis patients with peritonitis were entered in the study. Monocytes and polymorphonuclear cells were isolated from the patients' peritoneal effluent prior to initiation of any antibiotic therapy. Chemotaxis was measured by the Boyden chamber method before and after 2-hour incubation with cefodizime (200 mg/2L). Following 2-hour incubation with 200 mg/2L cefodizime, monocyte chemotaxis was increased from 36.8 +/- 5.6 mu m to 50.2 +/- 6.6 mu m (P = 0.0005). A similar increase was observed in polymorphonuclear cells from 42.0 +/- 8.8 mu m to 48.7 +/- 10.3 mu m (P = 0.02). We conclude that cefodizime acts as a priming agent on peritoneal polymorphonuclear cells, particularly on monocytes, and increases their chemotactic movements.

引用

页码：154 / 157

页数：4