Supplementation with selenium and coenzyme Q10 in critically ill patients

被引：15

作者：

Hargreaves, I. P. ^{[1
]}

Mantle, D. ^{[2
]}

机构：

[1] Liverpool John Moores Univ, Sch Pharm, Liverpool L3 3AF, Merseyside, England

[2] Pharma Nord UK Ltd, Morpeth, Newcastle, England

来源：

BRITISH JOURNAL OF HOSPITAL MEDICINE | 2019年 / 80卷 / 10期

关键词：

PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; MORTALITY; SELENOPROTEINS; INFLAMMATION; UBIQUINONE; SEPSIS; SAFETY; PHASE; Q(10);

D O I：

10.12968/hmed.2019.80.10.589

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple organ dysfunction and resultant mortality in critically ill patients has been linked with impaired cellular energy supply and oxidative stress. Clinical studies supplementing selenium, on the basis of its role as a key cofactor of antioxidant enzymes, have reported variable outcomes in critically ill patients. However, the synergistic interaction between selenium and coenzyme Q10, which has essential roles in cellular energy supply and as an antioxidant, has not been considered in such studies. This article reviews the link between selenium and coenzyme Q10, and the potential role of their co-supplementation in critical illness.

引用

页码：589 / 593

页数：5

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