Regulation of chromatin and gene expression by metabolic enzymes and metabolites

被引：339

作者：

Li, Xinjian ^{[1
]}

Egervari, Gabor ^{[2
,3
]}

Wang, Yugang ^{[1
]}

Berger, Shelley L. ^{[2
,3
,4
,5
]}

Lu, Zhimin ^{[1
,6
,7
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Brain Tumor Ctr, Houston, TX 77030 USA

[2] Univ Penn, Epigenet Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Cell & Mol Biol, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[7] Univ Texas Hlth Sci Ctr Houston, MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci, Houston, TX 77030 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2018年 / 19卷 / 09期

基金：

美国国家卫生研究院;

关键词：

PYRUVATE-KINASE M2; COVALENT HISTONE MODIFICATIONS; ACETYL-COA; LYSINE SUCCINYLATION; O-GLCNACYLATION; PROTEIN-KINASE; NUCLEAR TRANSLOCATION; LYSOSOMAL BIOGENESIS; DNA HYPOMETHYLATION; CELLULAR-METABOLISM;

D O I：

10.1038/s41580-018-0029-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.

引用

页码：563 / 578

页数：16

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