Immune Cell Metabolism in Tumor Microenvironment

被引：26
|
作者：
Li, Yongslieng [1 ]
Wan, Yisong Y. [2 ]
Zhu, Bo [1 ]
机构：
[1] Third Mil Med Univ, Xinqiao Hosp, Inst Canc, Chongqing, Peoples R China
[2] Univ North Carolina Chapel Hill, Lineberger Comprehen Canc Ctr, Chapel Hill, NC USA
来源：
IMMUNE METABOLISM IN HEALTH AND TUMOR | 2017年 / 1011卷
关键词：
Immune cell metabolism; Tumor microenvironment; Cancer stein cells; Clinical diagnosis; Drug repositioning; FATTY-ACID OXIDATION; CANCER-ASSOCIATED FIBROBLASTS; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; PYRUVATE-KINASE M2; SUPPRESSOR-CELLS; NITRIC-OXIDE; MACROPHAGE POLARIZATION; ALTERNATIVE ACTIVATION; GLUTAMINE-METABOLISM;
D O I：
10.1007/978-94-024-1170-6_5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell functions and edits tumor immunology. Recent findings in immune cell metabolism hold the promising possibilities toward clinical therapeutics for treating cancer. This chapter introduces the updated understandings of metabolic reprogramming of immune cells in the TME and suggests new directions in manipulation of immune responses for cancer diagnosis and therapy.
引用
收藏
页码：163 / 196
页数：34
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