Regioselective reduction of N-alkyl-3-sulfonyl-glutarimide.: Formal synthesis of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen

被引：0
作者：
Chang, MY
Chen, ST [1 ]
Chang, NC
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan
[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan
来源：
HETEROCYCLES | 2003年 / 60卷 / 01期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reduction of N-alkyl-3-sulfonylglutarimides with (1) sodium hydride and then with lithium aluminum hydride, or (2) sodium borohydride yielded two different types of regioselectively reduced hydroxypiperidinones which were further dehydrated to two pyridin-2-ones in the presence of boron trifluoride etherate. Cycloaddition and regioselective reduction were combined to synthesize 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen.
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页码：99 / 112
页数：14
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