The Role of Polymorphisms Within Paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the Modulation of Cardiovascular Risk: A Pilot Study

被引：42

作者：

Gluba, Anna ^{[2
]}

Pietrucha, Tadeusz

Banach, Maciej ^{[1
]}

Piotrowski, Grzegorz ^{[3
]}

Rysz, Jacek ^{[2
]}

机构：

[1] Med Univ Lodz, Dept Hypertens, PL-90549 Lodz, Poland

[2] Med Univ Lodz, Dept Nephrol Hypertens & Family Med, PL-90549 Lodz, Poland

[3] M Kopernik Prov Specialist Hosp Lodz, Dept Cardiol, Lodz, Poland

来源：

ANGIOLOGY | 2010年 / 61卷 / 02期

关键词：

cardiovascular disease; cholesterol profile; paraoxonase; polymorphisms; gene; HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; MYOCARDIAL-INFARCTION RISK; APOLIPOPROTEIN-A-I; HEART-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; GLN-ARG192; POLYMORPHISM; GENE POLYMORPHISMS; PARENTAL HISTORY;

D O I：

10.1177/0003319709351258

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Paraoxonases (PONs) may exert anti-atherogenic action by reducing lipid peroxidation. We evaluated the influence of 2 polymorphisms within PON1 (192 Gln/Arg) and PON2 (311 Ser/Cys) genes in 407 young Poles: 273 patients who experienced a first myocardial infarction (MI) under the age of 45 (study group) and 134 healthy volunteers (control group) with a HEART Score <= 2 (low risk). Paraoxonase 1 polymorphism 192Gln/Arg influenced the risk of premature MI (P=.0054). A positive family history of coronary artery disease (CAD) was associated with the 192Arg allele (P=.0107). The association between PON1 genotype 192 Gln/Arg) and low-density lipoprotein cholesterol (LDL-C) (P=.036) levels was also observed. However, we did not find any relationship between polymorphism 311Ser/Cys and CAD risk (P=.418). PON1 polymorphism 192Gln/Arg influenced the risk of premature MI. The association between PON1 genotype ( 192 Gln/Arg) and serum LDL-C levels may be explained by PON participation in reverse cholesterol transport.

引用

页码：157 / 165

页数：9

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