Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63

被引：100
作者：
McGwire, BS
Chang, KP
Engman, DM
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Immunol Microbiol, Chicago, IL 60611 USA
[3] Univ Illinois, Coll Med, Infect Dis Sect, Chicago, IL 60612 USA
[4] Univ Hlth Sci, Dept Microbiol & Immunol, N Chicago, IL 60064 USA
来源：
INFECTION AND IMMUNITY | 2003年 / 71卷 / 02期
关键词：
D O I：
10.1128/IAI.71.2.1008-1010.2003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Leishmania species engineered to express high levels of the surface metalloprotease gp63 have enhanced capacity of migration through extracellular matrix in vitro. This correlates with gp63 degradation of extracellular matrix components, such as collagen type IV and fibronectin, and suggests an important role for gp63 in the pathogenesis of leishmaniasis.
引用
收藏
页码：1008 / 1010
页数：3
相关论文
共 16 条
[1]   High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences [J].
Bandyopadhyay, K ;
Karmakar, S ;
Ghosh, A ;
Das, PK .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (06) :1622-1629
[2]   Interaction of Leishmania gp63 with cellular receptors for fibronectin [J].
Brittingham, A ;
Chen, G ;
McGwire, BS ;
Chang, KP ;
Mosser, DM .
INFECTION AND IMMUNITY, 1999, 67 (09) :4477-4484
[3]  
BRITTINGHAM A, 1995, J IMMUNOL, V155, P3102
[4]   RECOMBINANT LEISHMANIA SURFACE GLYCOPROTEIN GP63 IS SECRETED IN THE BACULOVIRUS EXPRESSION SYSTEM AS A LATENT METALLOPROTEINASE [J].
BUTTON, LL ;
WILSON, G ;
ASTELL, CR ;
MCMASTER, WR .
GENE, 1993, 134 (01) :75-81
[5]   MONOCLONAL-ANTIBODY AFFINITY PURIFICATION OF A LEISHMANIA MEMBRANE GLYCOPROTEIN AND ITS INHIBITION OF LEISHMANIAMACROPHAGE BINDING [J].
CHANG, CS ;
CHANG, KP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (01) :100-104
[6]  
CHANG KP, 1990, ANNU REV MICROBIOL, V44, P499, DOI 10.1146/annurev.mi.44.100190.002435
[7]   ACID PROTEASE ACTIVITY OF A MAJOR SURFACE-MEMBRANE GLYCOPROTEIN (GP63) FROM LEISHMANIA-MEXICANA PROMASTIGOTES [J].
CHAUDHURI, G ;
CHANG, KP .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1988, 27 (01) :43-52
[8]  
CHAUDHURI G, 1989, J BIOL CHEM, V264, P7483
[9]   Isolation of a laminin-binding protein from the protozoan parasite Leishmania donovani that may mediate cell adhesion [J].
Ghosh, A ;
Bandyopadhyay, K ;
Kole, L ;
Das, PK .
BIOCHEMICAL JOURNAL, 1999, 337 :551-558
[10]   EXTRACHROMOSOMAL GENETIC COMPLEMENTATION OF SURFACE METALLOPROTEINASE (GP63)-DEFICIENT LEISHMANIA INCREASES THEIR BINDING TO MACROPHAGES [J].
LIU, X ;
CHANG, KP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :4991-4995
12