A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light

被引:716
作者
Albrecht, U
Sun, ZS
Eichele, G
Lee, CC [1 ]
机构
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem, Houston, TX 77030 USA
[3] Max Planck Inst Expt Endocrinol, D-30625 Hannover, Germany
关键词
D O I
10.1016/S0092-8674(00)80495-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.
引用
收藏
页码:1055 / 1064
页数:10
相关论文
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