Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma

被引：2

作者：

Khan, Mostafa J. ^{[1
]}

Desaire, Heather ^{[2
]}

Lopez, Oscar L. ^{[3
,4
]}

Kamboh, M. Ilyas ^{[4
,5
,6
]}

Robinson, Rena A. S. ^{[1
,7
,8
,9
,10
]}

机构：

[1] Vanderbilt Univ, Dept Chem, 5423 Stevenson Ctr, Nashville, TN 37235 USA

[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

[3] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15213 USA

[6] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA

[7] Vanderbilt Univ, Med Ctr, Vanderbilt Memory & Alzheimers Ctr, Nashville, TN 37212 USA

[8] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA

[9] Vanderbilt Univ, Med Ctr, Vanderbilt Brain Inst, Nashville, TN 37232 USA

[10] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN 37232 USA

来源：

DATA IN BRIEF | 2021年 / 35卷

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Plasma; Proteomics; Biomarker; African American; Black; disparities;

D O I：

10.1016/j.dib.2021.106923

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here we present a plasma proteomics dataset that was generated to understand the importance of self-reported race for biomarker discovery in Alzheimer's disease. This dataset is related to the article "Why inclusion matters for Alzheimer's disease biomarker discovery in plasma"[1]. Plasma samples were obtained from clinically diagnosed Alzheimer's disease and cognitively normal adults of African American/Black and non-Hispanic White racial and ethnic backgrounds. Plasma was immunodepleted, digested, and isobarically tagged with commercial reagents. Tagged peptides were fractionated using high pH fractionation and resulting fractions analysed by liquid chromatography - mass spectrometry (LC-MS/MS & MS3) analysis on an Orbitrap Fusion Lumos mass spectrometer. The resulting data was processed using Proteome Discoverer to produce a list of identified proteins with corresponding tandem mass tag (TMT) intensity information. (c) 2021 The Authors. Published by Elsevier Inc.

引用

页数：8

共 5 条

[1]

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Desaire, Heather ;

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