Visible-light photocatalytic α-amino C(sp3)-H activation through radical translocation: a novel and metal-free approach. to α-allcoxybenzamides

被引：28
作者：
Huang, Feng-Qing [1 ]
Dong, Xin [1 ]
Qi, Lian-Wen [1 ]
Zhang, Bo [1 ]
机构：
[1] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Xiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Photochemistry; C-H activation; C-O bond formation; Radical reactions; Visible light; C-H ARYLATION; N-BOC-PYRROLIDINE; PHOTOREDOX CATALYSIS; QUINOLIZIDINE ALKALOIDS; COUPLING REACTION; ROOM-TEMPERATURE; POLAR CROSSOVER; FUNCTIONALIZATION; BONDS; SALTS;
D O I：
10.1016/j.tetlet.2016.02.108
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Visible-light photocatalytic, metal-free synthesis of valuable alpha-alkoxybenzamides starting with readily prepared o-aminobenzamides and alcohols through radical translocation under mild conditions is reported. This protocol employs eosin Y as an organophotoredox catalyst and readily available tert-butyl nitrite as the nitrosating reagent. These transformations occur in the absence of any transition metal and the title compounds are obtained in moderate to good yields. (C) 2016 Elsevier Ltd. All rights reserved.
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页码：1600 / 1604
页数：5
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