Glycemic control in patients with insulinoma

被引：33
作者：
Matej, Agata [1 ]
Bujwid, Hanna [2 ]
Wronski, Jakub [3 ]
机构：
[1] Prof W Orlowski Hosp, Warsaw, Poland
[2] Wolski Hosp, Warsaw, Poland
[3] Warsaw Med Univ, Dept Disaster Med, Warsaw, Poland
来源：
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2016年 / 15卷 / 04期
关键词：
Insulinoma; Glycemic control; Hypoglycemia; Hyperinsulinism; Pharmacotherapy; PANCREATIC NEUROENDOCRINE TUMORS; ENETS CONSENSUS GUIDELINES; MALIGNANT INSULINOMA; METASTATIC INSULINOMA; MEDICAL-TREATMENT; MANAGEMENT; HYPOGLYCEMIA; EVEROLIMUS; DIAZOXIDE; THERAPY;
D O I：
10.14310/horm.2002.1706
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulinoma is the most common neuroendocrine tumor of the pancreas. Surgical management of insulinomas is considered to be the only curative method. However, effective glycemic control preoperatively and in unresectable insulinomas remains a significant issue. Hyperinsulinism, occurring as a result of the hormone-secreting tumor, leads to life-threatening hypoglycemia episodes which require urgent medical treatment. This article discusses current management of hypoglycemia in insulinoma patients, including: education and lifestyle modifications, pharmacotherapy (diazoxide, somatostatin analogs, mTOR inhibitor - everolimus), cytoreductive methods and continuous glucose monitoring systems.
引用
收藏
页码：489 / 499
页数：11
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