Nlrp3: An immune sensor of cellular stress and infection

被引：121

作者：

Lamkanfi, Mohamed ^{[2
,3
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Univ Ghent VIB, Dept Med Prot Res, B-9000 Ghent, Belgium

[3] Univ Ghent VIB, Dept Biochem, B-9000 Ghent, Belgium

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 06期

关键词：

NLR; Nlrp3; Inflammasome; Caspase-1; Interleukin-1; COLD AUTOINFLAMMATORY SYNDROME; MUCKLE-WELLS-SYNDROME; HOST-DEFENSE; CRYOPYRIN INFLAMMASOME; CANDIDA-ALBICANS; ACTIVATION; RECOGNITION; CASPASE-1; DISEASE; INNATE;

D O I：

10.1016/j.biocel.2010.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Innate immune cells rely on pathogen recognition receptors such as the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family to mount an appropriate immune response against microbial threats The NLR protein Nlrp3 senses microbial ligands, endogenous danger signals and crystalline substances in the cytosol to trigger the assembly of a large caspase-1-activating protein complex termed the Nlrp3 inflammasome Autoproteolytic maturation of caspase-1 zymogens in the Nlrp3 inflammasome leads to maturation and extracellular release of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 Gain-of-function mutations in the NOD domain of Nlrp3 are associated with auto-inflammatory disorders characterized by skin rashes and prolonged episodes of fever In addition, decreased Nlrp3 expression was recently linked with susceptibility to Crohn's disease in humans. In this review, we discuss recent developments on the role of the Nlrp3 inflammasome in innate immunity, its activation mechanisms and the auto-inflammatory disorders associated with deregulation of Nlrp3 inflammasome activity (C) 2010 Elsevier Ltd All rights reserved

引用

页码：792 / 795

页数：4

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