Sex steroids as inflammatory regulators

被引：130

作者：

Gilliver, Stephen C. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 120卷 / 2-3期

关键词：

Sex steroids; Inflammation; Atherosclerosis; Wound healing; HORMONE-REPLACEMENT THERAPY; ESTROGEN-RECEPTOR-BETA; NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY ATHEROSCLEROSIS; HUMAN ENDOTHELIAL-CELLS; C-REACTIVE PROTEIN; CONJUGATED EQUINE ESTROGENS; MIGRATION INHIBITORY FACTOR; ADHESION MOLECULE-1 EXPRESSION; HUMAN NEUTROPHIL GRANULOCYTES;

D O I：

10.1016/j.jsbmb.2009.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is becoming increasingly clear that endogenous sex steroids are key players in a range of inflammatory contexts. Androgens and estrogens have been shown to have a profound influence on the function of inflammatory cells including macrophages and on the secretion and activation of a range of plasma-borne inflammatory mediators. The menopause and polymorphisms in estrogen receptor genes have separately been shown to affect the incidence of a range of inflammatory disorders. Sex steroids themselves have been shown to be protective in certain conditions: harmful in others. This review will summarize their documented effects on inflammatory processes, with particular focus on two areas that have received much recent attention: the antiatherosclerotic properties of estrogens in females and the wound healing effects of sex steroids. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：105 / 115

页数：11

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