Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease

被引:102
作者
Rodriguez-Calvo, Ricardo [1 ]
Girona, Josefa [1 ]
Alegret, Josep M. [2 ]
Bosquet, Alba [1 ]
Ibarretxe, Daiana [1 ]
Masana, Lluis [1 ]
机构
[1] Univ Rovira & Virgili, St Joan Univ Hosp,IISPV, Vasc Med & Metab Unit,Res Unit Lipids & Atheroscl, Spanish Biomed Res Ctr Diabet & Associated Metab, Reus, Spain
[2] Univ Rovira & Virgili, St Joan Univ Hosp, IISPV, Dept Cardiol,Cardiovasc Res Grp, Reus, Spain
关键词
heart failure; cardiovascular disease; adipokines; FABP4; BODY-MASS INDEX; CORONARY-ARTERY-DISEASE; VENTRICULAR DIASTOLIC DYSFUNCTION; ACTIVATED RECEPTOR-GAMMA; METABOLIC SYNDROME; APOLIPOPROTEIN-E; PRACTICE GUIDELINES; INSULIN-RESISTANCE; CIRCULATING FABP4; PHYSICAL-ACTIVITY;
D O I
10.1530/JOE-17-0031
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity and ectopic fat accumulation in non-adipose tissues are major contributors to heart failure (HF) and cardiovascular disease (CVD). Adipocytes act as endocrine organs by releasing a large number of bioactive molecules into the bloodstream, which participate in a communication network between white adipose tissue and other organs, including the heart. Among these molecules, fatty acid-binding protein 4 (FABP4) has recently been shown to increase cardiometabolic risk. Both clinical and experimental evidence have identified FABP4 as a relevant player in atherosclerosis and coronary artery disease, and it has been directly related to cardiac alterations such as left ventricular hypertrophy (LVH) and both systolic and diastolic cardiac dysfunction. The available interventional studies preclude the establishment of a direct causal role of this molecule in CVD and HF and propose FABP4 as a biomarker rather than as an aetiological factor. However, several experimental reports have suggested that FABP4 may act as a direct contributor to cardiac metabolism and physiopathology, and the pharmacological targeting of FABP4 may restore some of the metabolic alterations that are conducive to CVD and HF. Here, we review the current knowledge regarding FABP4 in the context of HF and CVD as well as the molecular basis by which this protein participates in the regulation of cardiac function.
引用
收藏
页码:R173 / R184
页数:12
相关论文
共 124 条
[1]   Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor γ agonists in cultured cell [J].
Adida, A ;
Spener, F .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2006, 1761 (02) :172-181
[2]   Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis [J].
Agardh, H. E. ;
Folkersen, L. ;
Ekstrand, J. ;
Marcus, D. ;
Swedenborg, J. ;
Hedin, U. ;
Gabrielsen, A. ;
Paulsson-Berne, G. .
JOURNAL OF INTERNAL MEDICINE, 2011, 269 (02) :200-210
[3]   Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARγ by FABP4 [J].
Ayers, Stephen D. ;
Nedrow, Katherine L. ;
Gillilan, Richard E. ;
Noy, Noa .
BIOCHEMISTRY, 2007, 46 (23) :6744-6752
[4]   Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects [J].
Baessler, A. ;
Lamounier-Zepter, V. ;
Fenk, S. ;
Strack, C. ;
Lahmann, C. ;
Loew, T. ;
Schmitz, G. ;
Blueher, M. ;
Bornstein, S. R. ;
Fischer, M. .
NUTRITION & DIABETES, 2014, 4 :e106-e106
[5]   Relation of Plasma Fatty Acid Binding Proteins 4 and 5 With the Metabolic Syndrome, Inflammation and Coronary Calcium in Patients With Type-2 Diabetes Mellitus [J].
Bagheri, Roshanak ;
Qasim, Atif N. ;
Mehta, Nehal N. ;
Terembula, Karen ;
Kapoor, Shiv ;
Braunstein, Seth ;
Schutta, Mark ;
Iqbal, Nayyar ;
Lehrke, Michael ;
Reilly, Muredach P. .
AMERICAN JOURNAL OF CARDIOLOGY, 2010, 106 (08) :1118-1123
[6]   Novel metabolic risk factors for incident heart failure and their relationship with obesity [J].
Bahrami, Hossein ;
Bluemke, David A. ;
Kronmal, Richard ;
Bertoni, Alain G. ;
Lloyd-Jones, Donald M. ;
Shahar, Eyal ;
Szklo, Moyses ;
Lima, Joao A. C. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (18) :1775-1783
[7]   Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Independently Associated With Left Ventricular Mass and Myocardial Performance Index in Obstructive Sleep Apnea Syndrome [J].
Balci, Mustafa Mucahit ;
Arslan, Ugur ;
Firat, Hikmet ;
Kocaoglu, Ibrahim ;
Vural, Mustafa Gokhan ;
Balci, Kevser Gulcihan ;
Maden, Orhan ;
Gurbuz, Oguz Alp ;
Ardic, Sadik ;
Yeter, Ekrem .
JOURNAL OF INVESTIGATIVE MEDICINE, 2012, 60 (07) :1020-1026
[8]   Adiponectin in outpatients with coronary artery disease: Independent predictors and relationship with heart failure [J].
Baldasseroni, S. ;
Mannucci, E. ;
Orso, F. ;
Di Serio, C. ;
Pratesi, A. ;
Bartoli, N. ;
Marella, G. A. ;
Colombi, C. ;
Foschini, A. ;
Valoti, P. ;
Mossello, E. ;
Fumagalli, S. ;
Marchionni, N. ;
Tarantini, F. .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2012, 22 (03) :292-299
[9]   Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Associated with the Severity of Coronary Artery Disease in Chinese Women [J].
Bao, Yuqian ;
Lu, Zhigang ;
Zhou, Mi ;
Li, Huating ;
Wang, Ye ;
Gao, Meifang ;
Wei, Meng ;
Jia, Weiping .
PLOS ONE, 2011, 6 (04)
[10]   N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors [J].
Barf, Tjeerd ;
Lehmann, Fredrik ;
Hammer, Kristin ;
Haile, Saba ;
Axen, Eva ;
Medina, Carmen ;
Uppenberg, Jonas ;
Svensson, Stefan ;
Rondahl, Lena ;
Lundbaeck, Thomas .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) :1745-1748