Measuring immune responses to pneumococcal vaccines

被引：42

作者：

LaFon, David C. ^{[1
]}

Nahm, Moon H. ^{[1
,2
]}

机构：

[1] Univ Alabama Birmingham, Div Pulm Allergy & Crit Care Med, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL USA

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 2018年 / 461卷

关键词：

Streptococcus pneumoniae; Pneumococcal; Vaccine; Immune response; Immune deficiency; LINKED-IMMUNOSORBENT-ASSAY; IMMUNIZATION PRACTICES ACIP; STANDARD REFERENCE SERUM; CONJUGATE VACCINE; POLYSACCHARIDE VACCINE; CAPSULAR POLYSACCHARIDES; PRIMARY IMMUNODEFICIENCY; ANALYTICAL VARIABILITY; ADVISORY-COMMITTEE; ANTIBODIES;

D O I：

10.1016/j.jim.2018.08.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative assays that measure immune response to pneumococcal vaccines are not only important for the evaluation of vaccine immunogenicity and efficacy, but are also utilized in the clinical diagnosis of immune deficiency syndromes. Analytical methods have progressed in order to meet changing demands in both of these areas, from early methods to ELISA, and most recently multiplex bead array assays and opsonophagocytosis assays (OPA). It is necessary to understand the evolution of such techniques and the criteria for their interpretation in order to better inform the application of currently available methods, and to guide future investigation into assay development.

引用

页码：37 / 43

页数：7

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