Factors influencing the immune response to foreign antigen expressed in recombinant BCG vaccines

被引：54
作者：
Dennehy, M
Williamson, AL
机构：
[1] Biovac Inst, ZA-7430 Cape Town, South Africa
[2] Univ Cape Town, Div Virol, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa
[3] Natl Hlth Lab Serv, ZA-7925 Cape Town, South Africa
来源：
VACCINE | 2005年 / 23卷 / 10期
基金：
新加坡国家研究基金会; 英国医学研究理事会;
关键词：
recombinant; BCG; Mycobacterium bovis;
D O I：
10.1016/j.vaccine.2004.08.039
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A wide range of recombinant BCG vaccine candidates containing foreign viral, bacterial, parasite or immunomodulatory genetic material have been developed and evaluated, primarily in animal models, for immune response to the foreign antigen. This review considers some of the factors that may influence the immunogenicity of these vaccines. The influence of levels and timing of expression of the foreign antigen and the use of targeting sequences are considered in the first section. Genetic and functional stability of rBCG is reviewed in the second section. In the last section, the influence of dose and route of immunization, strain of BCG and the animal model used are discussed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1209 / 1224
页数：16
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