Biosynthesis and biotechnological application of non-canonical amino acids: Complex and unclear

被引:26
作者
Zou, Huibin [1 ,2 ]
Li, Lei [1 ]
Zhang, Tongtong [1 ]
Shi, Mengxun [1 ]
Zhang, Nan [1 ]
Huang, Jingling [1 ]
Xian, Mo [2 ]
机构
[1] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China
[2] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
关键词
Non-canonical amino acids; Biosynthesis; Synthetic biology; GAMMA-AMINOBUTYRIC-ACID; ENZYMATIC-SYNTHESIS; ESCHERICHIA-COLI; L-CANAVANINE; NONRIBOSOMAL PEPTIDE; ASYMMETRIC-SYNTHESIS; GENE-CLUSTER; METABOLISM; HYDROXYPROLINE; PROTEINS;
D O I
10.1016/j.biotechadv.2018.07.008
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions. Due to their specific characteristics, a broader range of natural and artificial non-canonical amino acids have recently been applied in the development of functional materials and pharmaceutical products. With the rapid development of advanced methods in biotechnology, non-canonical amino acids can be incorporated into peptides, proteins and enzymes to improve the function and performance relative to their natural counterparts. Therefore, biotechnological application of non-canonical amino acids in artificial bio-macromolecules follows the central goal of synthetic biology to: create novel life forms and functions. However, many of the non-canonical amino acids are synthesized via chemo- or semi-synthetic methods, and few non-canonical amino acids can be synthesized using natural in vivo pathways. Therefore, further research is needed to clarify the metabolic pathways and key enzymes of the non-canonical amino acids. This will lead to the discovery of more candidate non-canonical amino acids, especially for those that are derived from microorganisms and are naturally bio-compatible with chassis strains for in vivo biosynthesis. In this review, we summarize representative natural and artificial non canonical amino acids, their known information regarding associated metabolic pathways, their characteristics and their practical applications. Moreover, this review summarizes current barriers in developing in vivo pathways for the synthesis of non-canonical amino acids, as well as other considerations, future trends and potential applications of non-canonical amino acids in advanced biotechnology.
引用
收藏
页码:1917 / 1927
页数:11
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