Chemical modifications of polysaccharides and their anti-tumor activities

被引：240

作者：

Xie, Liuming ^{[1
]}

Shen, Mingyue ^{[1
]}

Hong, Yuzhen ^{[1
]}

Ye, Hedan ^{[1
]}

Huang, Lixin ^{[1
]}

Xie, Jianhua ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2020年 / 229卷

基金：

中国国家自然科学基金;

关键词：

Polysaccharide; Chemical modification; Anti-tumor activity; Mechanism; DENDROBIUM-HUOSHANENSE POLYSACCHARIDE; KAPPA-CARRAGEENAN OLIGOSACCHARIDES; WATER-SOLUBLE POLYSACCHARIDE; PUMPKIN CUCURBITA-PEPO; ACTIVITIES IN-VITRO; SULFATED MODIFICATION; CYCLOCARYA-PALIURUS; ANTIOXIDANT ACTIVITIES; STRUCTURAL-CHARACTERIZATION; IMMUNOMODULATORY ACTIVITY;

D O I：

10.1016/j.carbpol.2019.115436

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

With the rising trend of incidence of cancers, effective therapies are urgently needed to control human malignancies. However, the chemotherapy drugs currently on the market cause serious side effects. Polysaccharides belong to a class of biomacromolecules, which have drawn considerable research interest over the years as it possess anti-cancer activities or can increase the efficacy of conventional chemotherapy drugs with fewer side effects. The antitumor activity of many polysaccharides was significantly increased after modification. Based on these encouraging observations, a great deal of effort has been focused on discovering anti-cancer polysaccharides and modified derivatives for the development of effective therapeutics for various human cancers. This review highlights recent advances on the major chemical modification methods of polysaccharides, and discusses the effect of molecular modification on the physicochemical properties and anti-tumor activities of polysaccharides. Meanwhile, the underlying anti-tumor mechanisms of polysaccharide and its modified derivatives were also discussed.

引用

页数：12

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