Epigenetic regulation of RET receptor tyrosine kinase and non-coding RNAs in MTC

被引：3

作者：

Joo, Lauren Jin Suk ^{[1
,2
]}

Zhao, Jing Ting ^{[1
,2
]}

Gild, Matti L. ^{[2
]}

Glover, Anthony R. ^{[2
]}

Sidhu, Stan B. ^{[1
,2
,3
]}

机构：

[1] Univ Sydney, Royal North Shore Hosp, Kolling Inst Med Res, Canc Genet Lab, St Leonards, NSW, Australia

[2] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch Northern, Sydney, NSW, Australia

[3] Univ Sydney, Royal North Shore Hosp, Endocrine Surg Unit, St Leonards, NSW 2065, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 469卷

关键词：

Medullary thyroid carcinoma; RET; Epigenetics; MicroRNA; Noncoding RNA; MEDULLARY-THYROID CARCINOMA; HISTONE DEACETYLASE INHIBITORS; CPG ISLAND METHYLATION; NODAL METASTASIS; CANCER; EXPRESSION; PROTOONCOGENE; MICRORNA; TUMOR; MANAGEMENT;

D O I：

10.1016/j.mce.2017.03.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Medullary thyroid carcinoma (MTC) is an aggressive and rare cancer with limited treatment options for metastatic disease. Due to this, there is a need for a better understanding of MTC biology in the hope of improved treatments. One area of improved understanding of cancer biology is epigenetics. Epigenetics is defined as cellular processes which alter gene expression independent of changes in the primary DNA sequence. These processes include modifications such as DNA methylation, microRNA deregulation and post-translational histone modifications, all of which have been implicated in tumorigenesis of MTC. Transcription of the main driver of MTC - the REarranged during Transfection (RET) proto-oncogene can also be modulated by epigenetic alterations. This review will present a review of MTC and its epigenetic links with a particular focus on targeting epigenetic mechanisms as novel therapeutic strategies. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：48 / 53

页数：6

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