Enantioselective synthesis of 1,2-diarylaziridines by the organocatalytic reductive amination of α-chloroketones

被引：85

作者：

Malkov, Andrei V. ^{[1
]}

Stoncius, Sigitas ^{[1
]}

Kocovsky, Pavel ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, WestChem, Glasgow G12 8QQ, Lanark, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

amination; asymmetric synthesis; aziridines; organocatalysis; reduction;

D O I：

10.1002/anie.200700165

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) One-sided triangles: A simple protocol has been developed for the synthesis of highly useful single enantiomers of 1,2-diarylaziridines. The method involves conversion of the readily available α-chloroacetophenones into the corresponding imines, followed by an enantioselective reduction with Cl3SiH catalyzed by the L-valine-derived formamide L* and ring closure to give the desired aziridines (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3722 / 3724

页数：3

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