Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation

被引：24

作者：

Hampton, RY ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol 0347, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 02期

关键词：

D O I：

10.1097/00041433-199804000-00003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydroxymethylglutaryl-coenzyme A reductase degradation occurs in the endoplasmic reticulum, and is regulated by the mevalonate pathway. In order to discover the molecules that mediate the degradation process and its control, we conducted a genetic analysis of the degradation of the yeast Hmg2p isozyme of hydroxymethylglutaryl-coenzyme A reductase. Hmg2p degradation occurs by the action of HRD genes that direct Hmg2p to the ubiquitin-proteasome pathway. Regulation of HRD-dependent Hmg2p degradation appears to occur by the action of a separate set of CRD genes. (C) 1998 Rapid Science Ltd.

引用

页码：93 / 97

页数：5

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