Presenting characteristics and clinical outcome of patients with COVID-19 in South Korea: A nationwide retrospective observational study

Background: More than 13,000 cases were reported to be infected with COVID-19 by RT-PCR in South Korea. Most studies report clinical characteristics of hospitalized patients with COVID-19; the full spectrum of disease severity has thus not yet been well described. Methods: Using retrospective observational methods, this study analyzed factors affecting early clinical symptoms, clinical progress, and severity of disease for COVID-19 positive patients released from quarantine to provide information on establishing optimized care for new patients. The medical data of 7803 laboratory-confirmed patients who had been discharged or died by April 30, 2020 were analyzed using multivariate logistic regression analysis. Findings: On admission, 7383 (94.5%) patients were asymptomatic or showed mild illness, and 372 (4.8%) patients were severe illness. Also, 48 (0 0.6%) were hospitalized with critically ill when diagnosed. Most patients with asymptomatic or mild illness on admission remained mild until discharge, 253 (3.4%) progressed to severe illness, and 83 (1.1%) died in hospital. However, the case fatality were 29.8% and 62.5% in severe and critically ill patients, respectively. At admission, 73.0% of hospitalized patients had symptoms; most common were cough (42.5%), sputum (28.8%), and fever (20.1%). Only 35.2% of laboratory confirmed patients admitted to the temporary care facility complained of symptoms. Increasing odds of being critically ill was associated with older age (OR 28.93, 95% CI 13.34-62.75 for age >70y, vs. age <50 y; p<0.0001), being male (OR 2.15, 95% CI1.59-2.89; p<0.0001), fever (OR 2.52, 95% CI 1.84-3.45; p<0.0001), and shortness of breath (OR 7.40, 95% CI 5.37-10.19; p<0.0001). Comorbid illness significantly increased risk of critical illness or death. Interpretation: Most cases were discharged as asymptomatic or recovered from mild illness, and only 9.7% developed severe disease requiring oxygen therapy or more. Case fatality rate was 2.9%, and markedly increased in those over age 50. Risk factors such as age, sex, fever, shortness of breath, and underlying disease can be useful in predicting future clinical severity. Additionally, the number of confirmed asymptomatic COVID-19 patients significantly contribute to continued spread. (C) 2020 The Authors. Published by Elsevier Ltd.