Stabilizing and destabilizing effects of drug-excipient interactions in spray-dried, freeze-dried, and granulated Sennae fructus extracts

被引：2
|
作者：
Zier, Kira-Isabel [1 ,2 ,3 ]
Schultze, Wulf [2 ]
Sazama, Uta [2 ,4 ]
Froeba, Michael [2 ,4 ]
Leopold, Claudia S. [1 ,2 ]
机构：
[1] Univ Hamburg, Div Pharmaceut Technol, Hamburg, Germany
[2] Univ Hamburg, Dept Chem, Hamburg, Germany
[3] Roha Arzneimittel GmbH, Div Pharmaceut Technol, Bremen, Germany
[4] Univ Hamburg, Div Inorgan & Appl Chem, Hamburg, Germany
来源：
DRYING TECHNOLOGY | 2020年 / 38卷 / 14期
关键词：
Sennae fructus extract; drug-excipient interaction; spray-drying; freeze-drying; granulation; PHYSICOCHEMICAL PROPERTIES; POWDER; MALTODEXTRIN; ENCAPSULATION; COMPATIBILITY;
D O I：
10.1080/07373937.2019.1693397
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The objective of this study was to compare spray-dried and freeze-dried extracts of Sennae fructus regarding the stability of the sennosides. Therefore, the influence of the addition of maltodextrin (MD) not only before the drying processes but also during fluidized bed granulation was investigated. Analysis of the hygroscopicities, the simultaneous TGA-DSC-MS data, and the influence of storage revealed that spray-dried extracts are more stable than freeze-dried extracts. The addition of MD led to an even better stability of the extracts. Lower amounts of MD are sufficient if applied onto the surface of the native extract during fluidized bed granulation.
引用
收藏
页码：1882 / 1890
页数：9
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