New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides

被引：135

作者：

Guram, Anil S. ^{[1
]}

Wang, Xiang ^{[1
]}

Bunel, Emilio E. ^{[1
]}

Faul, Margaret M. ^{[1
]}

Larsen, Robert D. ^{[1
]}

Martinelli, Michael J. ^{[1
]}

机构：

[1] Amgen Inc, Chem Res & Discovery, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 14期

关键词：

D O I：

10.1021/jo070341w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new air-stable PdCl2{PR2(Ph-R')}(2) complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10 000 TON).

引用

页码：5104 / 5112

页数：9

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