Anti-Human Rhinovirus Activity of Raoulic Acid from Raoulia australis

被引：6

作者：

Choi, Hwa Jung ^{[2
]}

Song, Jae-Hyoung ^{[3
]}

Lim, Chi-Hwan ^{[4
]}

Baek, Seung-Hwa ^{[3
]}

Kwon, Dur-Han ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immune Modulator Res Ctr, Taejon 305333, South Korea

[2] Daejeon Hlth Sci Coll, Dept Clin Lab Sci, Taejon, South Korea

[3] Wonkwang Univ, Profess Grad Sch Oriental Med, Dept Herbal Resources, Iksan, South Korea

[4] Chungnam Natl Univ, Coll Agr, Dept Bio Environm Chem, Taejon, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2010年 / 13卷 / 02期

关键词：

antiviral activity; human rhinovirus; raoulic acid; resistance; ENTEROVIRUSES; REPLICATION; PLECONARIL;

D O I：

10.1089/jmf.2009.1149

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Human rhinoviruses (HRVs), members of the Picornaviridae family, are composed of over 100 different virus serotypes. Until now there is no recorded clinically effective antiviral chemotherapeutic agent for treatment of diseases caused by HRVs. Our previous study of raoulic acid tested against serotype human rhinoviruses showed anti-HRV2 (species A) and - 3 (species B) activities. In this study, raoulic acid was found to possess broad-spectrum antiviral activity against six HRVs with a 50% inhibition concentration of less than 9.5 mu g/mL through inhibition of the cellular absorption of the HRV particles. Furthermore, the effect of raoulic acid on resistance of HRV5 exhibited to pleconaril was more pronounced than the effect on HRV1b, -6, -14, -15, and -40. However, ribavirin did possess weak antiviral activity against HRVs. Collectively, the results demonstrate that raoulic acid is a novel therapeutic candidate for two different groups of human rhinovirus.

引用

页码：326 / 328

页数：3

共 13 条

[1] DRUGS AGAINST RHINOVIRUSES [J].

ALNAKIB, W ;

TYRRELL, DAJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 30 (02) :115-117

[2] LACK OF QUANTITATIVE CORRELATION BETWEEN INHIBITION OF REPLICATION OF RHINOVIRUSES BY AN ANTIVIRAL DRUG AND THEIR STABILIZATION [J].

ANDRIES, K ;

DEWINDT, B ;

SNOEKS, J ;

WILLEBRORDS, R .

ARCHIVES OF VIROLOGY, 1989, 106 (1-2) :51-61

[3] 2 GROUPS OF RHINOVIRUSES REVEALED BY A PANEL OF ANTIVIRAL COMPOUNDS PRESENT SEQUENCE DIVERGENCE AND DIFFERENTIAL PATHOGENICITY [J].

ANDRIES, K ;

DEWINDT, B ;

SNOEKS, J ;

WOUTERS, L ;

MOEREELS, H ;

LEWI, PJ ;

JANSSEN, PAJ .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1117-1123

[4] Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses [J].

Choi, H. J. ;

Lim, C. H. ;

Song, J. H. ;

Baek, S. H. ;

Kwon, D. H. .

PHYTOMEDICINE, 2009, 16 (01) :35-39

[5] Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus [J].

Choi, Hwa-Jung ;

Kim, Jin-Hee ;

Lee, Choong-Hwan ;

Ahn, Young-Joon ;

Song, Jae-Hyoung ;

Baek, Seung-Hwa ;

Kwon, Dur-Han .

ANTIVIRAL RESEARCH, 2009, 81 (01) :77-81

[6] Selective Inhibitors of Picornavirus Replication [J].

De Palma, Armando M. ;

Vliegen, Inge ;

De Clercq, Erik ;

Neyts, Johan .

MEDICINAL RESEARCH REVIEWS, 2008, 28 (06) :823-884

[7] The economic burden of non-influenza-related viral respiratory tract infection in the United States [J].

Fendrick, AM ;

Monto, AS ;

Nightengale, B ;

Sarnes, M .

ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (04) :487-494

[8] The common cold [J].

Heikkinen, T ;

Järvinen, A .

LANCET, 2003, 361 (9351) :51-59

[9] Phylogenetic analysis of human rhinovirus capsid protein VP1 and 2A protease coding sequences confirms shared genus-like relationships with human enteroviruses [J].

Laine, P ;

Savolainen, C ;

Blomqvist, S ;

Hovi, T .

JOURNAL OF GENERAL VIROLOGY, 2005, 86 :697-706

[10] Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril [J].

Ledford, RM ;

Collett, MS ;

Pevear, DC .

ANTIVIRAL RESEARCH, 2005, 68 (03) :135-138

← 1 2 →