Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

被引：13

作者：

Sierksma, Annerieke S. R. ^{[1
]}

de Nijs, Laurence ^{[1
]}

Hoogland, Govert ^{[1
,2
]}

Vanmierlo, Tim ^{[1
]}

van Leeuwen, Fred W. ^{[1
]}

Rutten, Bart P. F. ^{[1
]}

Steinbusch, Harry W. M. ^{[1
]}

Prickaerts, Jos ^{[1
]}

van den Hove, Daniel L. A. ^{[1
,3
]}

机构：

[1] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNS, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Neurosurg, NL-6200 MD Maastricht, Netherlands

[3] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97070 Wurzburg, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2016年 / 51卷 / 03期

关键词：

Alzheimer's disease; APPswe/PS1dE9; epilepsy; fluoxetine; premature death; seizure; CLINICAL-TRIAL; ALZHEIMERS-DISEASE; TRANSGENIC MICE; DOUBLE-BLIND; ANTIDEPRESSANTS; DEMENTIA; RATS; COGNITION; EPILEPSY; STRESS;

D O I：

10.3233/JAD-151066

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function. However, the mechanisms underlying these effects are largely unknown. To unravel these mechanisms, we aimed to treat APPswe/PS1dE9 mice with fluoxetine. Unexpectedly, with time, an increased number of animals displayed seizure behavior and died. Although spontaneous behavioral seizures have been reported previously in this mouse model, the observation of seizures and death consequential to fluoxetine treatment is new. Our results warrant further research on the underlying mechanisms as this may refine the treatment of AD patients.

引用

页码：677 / 682

页数：6

共 44 条

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