Palladium-catalyzed borylation of phenyl bromides and application in one-pot Suzuki-Miyaura biphenyl synthesis

被引：110

作者：

Broutin, PE ^{[1
]}

Cerna, I ^{[1
]}

Campaniello, M ^{[1
]}

Leroux, F ^{[1
]}

Colobert, F ^{[1
]}

机构：

[1] Univ Strasbourg 1, ECPM, CNRS, UMR 7008,Lab Stereochim, F-67087 Strasbourg 2, France

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 24期

关键词：

D O I：

10.1021/ol048303b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)(2) together with DPEphos as ligand and Et3N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields.

引用

页码：4419 / 4422

页数：4

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