Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

被引：27

作者：

Gibbons, S ^{[1
]}

Leimkugel, J ^{[1
]}

Oluwatuyi, M ^{[1
]}

Heinrich, M ^{[1
]}

机构：

[1] Univ London Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

来源：

PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 03期

关键词：

benzo[c]phenanthridine alkaloids; chelerythrine; efflux; MRSA; Nor(A); Msr(A); Tet(K); multidrug resistance; mdr;

D O I：

10.1002/ptr.1112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：274 / 275

页数：2

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