Antisense oligonucleotides

被引：2

作者：

Kashihara, N ^{[1
]}

Maeshima, Y ^{[1
]}

Makino, H ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Med 3, Okayama 700, Japan

来源：

EXPERIMENTAL NEPHROLOGY | 1998年 / 6卷 / 01期

关键词：

antisense oligonucleotides; gene therapy; liposomes;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense oligonucleotides. This technique was originally used to elucidate the function of a target gene, but may also have therapeutic applications, provided it is designed carefully and properly.

引用

页码：84 / 88

页数：5

共 30 条

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